Econazole dosing

Gouveia DC, Jones da SUva C. Oxiconazole in the treatment of vaginal candidiasis single dose versus 3-day treatment with econazole. Pharmatherapeutica 1984 3(10) 682-5. 

On the other hand, SEPA (2-n-nonyl-l,3-dioxolane) has been shown to be a more versatile penetration enhancer in terms of its ease of formulation, chemical stability and its ability to enhance the skin penetration of a wide variety of compounds of varying physicochemical characteristics. Permeants that have been evaluated include indomethacin, ibuprofen, minoxidil, acyclovir, caffeine, econazole, papaverine, progesterone and estradiol. The degree of skin penetration enhancement using SEPA is dependent on the physicochemical characteristics of the permeant. For example, following application of indomethacin in a simple ethanol-propylene glycol vehicle to human skin in vitro, cumulative absorption over 24 h amounted to 0.7 percent of the applied dose. The addition of 2 percent SEPA to the vehicle increased the 24 h absorption value to 23 percent of the applied dose (Marty et al. 1989). Furthermore, in comparative studies between SEPA and Azone, SEPA was shown to be a more effective human skin permeation enhancer for indomethacin (Figure 14.6, Marty et al. 1989). 

Econazole is the deschloro derivative of miconazole. Econazole readily penetrates the stratum comeum and achieves effective concentrations down to the mid-dermis. Less than 1% of an applied dose is absorbed into the blood. Approximately 3% of recipients have local erythema, burning, stinging, or itching. Econazole nitrate (spectazoie, others) is available as a water-miscible cream (1%) to be applied twice a day. 

After topical application to the skin of normal subjects, systemic absorption was extremely low and less than 1% of the applied dose of econazole was recovered in the urine and faeces. Systemically administered econazole does inhibit cytochrome P450 isoenzymes, but because of the low systemic availability after topical application, one manufacturer notes that clinically relevant interactions are rare. ... 

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