ECLIA immunoassays

Based on many of the advances described above in electrochemical approaches to immunoassay, it is tempting to conclude that commercialization of some of the approaches is imminent. This may be true, but the historical use of optical methods for many clinical chemistry tests coupled with their rapidly growing use in immunoassay is a difficult barrier for any radically different method to overcome, though electrochemical sensors have become more important in the clinical chemistry laboratory over the last decade. In any event, to be successful ECIA methods will have to demonstrate clear superiority over existing and emerging technologies in both cost and performance. Some of the more recently described approaches such as those using enzyme amplified amperometric detection and ecLIA appear... 

An example for an anti-HBe test with a direct label is the electrochemiluminescence immunoassay ECLIA from Roche Diagnostics (automated on Elecsys immunoassay analyser), whereas the Im-mulite anti-HBe test from Diagnostics Products Corp. represents an enzyme-amplified chemiluminescence immunoassay with sustained signal (automated on the Immulite chemiluminescent system). 

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