E Gel-Cream

MANUFACTURING DIRECTIONS 2. Maintain cool until the air bubbles escape. A 

Handbook of Pharmaceutical Manufacturing Formulations Semisolid Products 

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Fluocinonide 0.05% Lidex anhydrous cream, gel, soln 0.05% Lidex-E aqueous cream 0.05% High... 

It is proposed that the most prudent method for preserving the safety and efficacy of drug products is to assure the immediate packaging which provides this protection wherever possible. Even when this goal is achieved, there is no guarantee that the product after application (e.g., creams, ointments, and gels) will remain photostable. 

Pharmaceutical vehicles (e.g., creams, gels, lotions, or solutions) can decrease the amount of light reflected, scattered, or absorbed in the skin1819 or increase the percutaneous absorption of drugs in the skin of humans and mice.20,21... 

Drug Product—Finished dosage form (e.g., cream, gel, or ointment) in its marketed package. It also can be a finished dosage form (e.g., tablet, capsule, or solution) that contains a drug substance, generally, but not necessarily, in association with one or more other ingredients (21 CFR 314.3(b))... 

Release controls for nasal ointments and gels are similar to those on the corresponding cutaneous preparations, i.e. gels and creams (see Sect. 12.6.5). 

The primarily application of poly(acrylic acid) is as a viscosity modifier in the formulation of topical pharmaceutical products, (e.g., creams, gels), that are designed for applieation to local sites, (e.g., skin, eye, rectum) (a.4). The viscosity of poly(acrylic acid) is dependent on pH. At low pH poly(acrylie acid) forms colloidal dispersions of low viscosity, however, following neutralisation with a suitable... 

Photostability studies have been performed in diluted solutions of pure UV filters, in semisolid formulations (i.e. emulsions) prepared in the laboratory and in commercial products (e.g. creams, gels, sticks and oils). It should be noted that the type of sample markedly influences the UV filter photodecomposition (Schwack and Rudolph, 1995 Berset et al, 1996 Scalia et al, 1999 Serpone et al, 2002). 

Cidofovir (Fig. 2) has been formally approved for the treatment of CMV retinitis in AIDS patients, where it is administered intravenously at a dose not exceeding 5 mg/kg once weekly during the first two weeks (and every other week thereafter). Cidofovir is also used off label for the treatment of human papilloma virus (HPV) infections (i.e., cutaneous warts, anogenital warts, laryngeal and pharyngeal papilloma), polyomavirus [i.e., progressive (i.e., multifocal leukoencephalopathy (PML)], adenovirus, herpesvirus, and poxvirus (i.e., molluscum contagiosum) infections, where it can be administered intravenously (at a dose of < 5 mg/kg once weekly or every other week) or topically as a 1% gel or cream (De Clercq and Holy 2005). Especially in immunosuppressed patients (i.e., transplant recipients), local treatment of HPV-associated lesions has often yielded spectacular results (Bonatti etal.2007). 

Eccleston GM, Behan-Martin MK, Jones GR, Towns-Andrews E. Synchrotron X-ray investigations into the lamellar gel phase formed in pharmaceutical creams prepared with cetrimide and fatty alcohols. Int J Pharm 2000 203 127-139. 

Structure Forming Excipient An excipient which participates in the formation of the structural matrix which gives an ointment, cream or gel etc., its semisolid character. Examples are gel fonning polymers, petrolatum, certain colloidal inorganic solids (e.g., bentonite), waxy solids (e.g., cetyl alcohol, stearic acid), and emulsifiers used in creams. 

Set up a circus of gels, sols, emulsions and foams, e.g. jelly , milk, pumice stone, polyurethane foam, bread, emulsion paint, cola, hair cream, aerosol dispenser, salad cream. A silica gel can be made from sodium silicate and hydrochloric acid. Classify the examples according to type of colloidal system. 

Aluminum tubes are often used as the immediate package for dermal preparations. One important point to remember is that after the application of creams, ointments, or gels to the skin, all of the photo protection provided by the packaging is lost and photodegradation can occur. Topically applied drug substances with proven photoinstability, e.g., corticosteroids (36), retinoic acid (37), dithranol (38), and anti-mycotics (natamycine and nystatine) (39) fall into this category. 

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