E aminocaproic acid

By use of potassium phthalimide we can isolate the intermediate. a-Oxo-S-aminovaleric (9, = 1) and a-oxo-e-aminocaproic acids (9, = 2) readily yield 2l -pyrroline-2-carboxylic acid (10, =1) and. d -piperideine-2-carboxylic acids (10, n = 2), respectively (7-10). The equilibria of the acids with their cyclic forms was observed in water solutions (11,12). 

Ion exchange in the preparation of e-aminocaproic acid, 32, 13 Isoamylacetylene, 30, 17 2H-IS0AZEPINE, 3,4,5,6-tetrahydro-7-methoxy-, 31, 72 Isobutyranilide, 33, 30 Isobutyric acid, 33, 29... 

Aminobutyraldehyde diethyl acetal, d299 e-Aminocaproic acid, al83... 

The matching between the guest molecules and the host structure was also considered to explain the in situ polymerization of e-aminocaproic acid in zirconium phosphate [29]. The schematic representation of the arrangement... 

Fig. 4 Schematic representation of the arrangement of e-aminocaproic acid in zirconium phosphate in the layer-parallel phase (Reprinted from [29] with permission from ACS)...

Poly(e-caprolactam) orpoly(e-aminocaproic acid) depending on the source of polymer Poly[imino(l-oxohexane-l,6-diyl)]... 

The overall rate of conversion of e-caprolactam to polymer is higher than the polymerization rate of e-aminocaproic acid by more than an order of magnitude [Hermans et al., 1958, I960]. Step polymerization of e-aminocaproic acid with itself (Eq. 7-57) accounts for only a few percent of the total polymerization of e-caprolactam. Ring-opening polymerization (Eq. 7-58) is the overwhelming route for polymer formation. Polymerization is acid-catalyzed as indicated by the observations that amines and sodium e-aminocaproate are poor initiators in the absence of water and the polymerization rate in the presence of water is first-order in lactam and second-order in COOH end groups [Majury, 1958]. 

Although step polymerization of e-aminocaproic acid with itself is only a minor contribution to the overall conversion of lactam to polymer, it does determine the final degree of polymerization at equilibrium since the polymer undergoes self-condensation. The final... 

Medium-size members of homologous polymeric series such as dimers, trimers, etc. are called oligomers. They can be linear or cyclic and are often found as byproducts of polymer syntheses, e.g., in cationic polymerizations of trioxane or in polycondensations of e-aminocaproic acid (see Example 4-9). For the preparation of linear oligomers with two generally reactive end groups, the so-called telechelics, special methods, i.e., oligomerizations, were developed. 

Preparation of an Aliphatic Polyamide by Polycondensation of e-Aminocaproic Acid in the Melt... 

Add a sufficient amount of the hydrazide (e.g., 0.2 pg/ml of digoxigenin hydrazide (digoxigenin-succinyl-e-aminocaproic acid hydrazide) or 25pg/ml of Biotin-LC-Hydrazide ) and incubate for 1 h at RT. Wash three times for 10 min with Soln. D and block the membranes for 15 min with an appropriate blocking solution, e.g., 1% non-fat dry milk in Soln. D. Wash with Soln. D. 

In principle every compound with an amino and a carboxy group can be used for such purpose ranging from simple co-amino acids [e.g., 5-aminopentanoic acid (6-aminovaleric acid) (1, n = 3)]1541 or 6-aminohexanoic acid (e-aminocaproic acid) (1, n = 4)]135,57,4 791 and related derivatives of 3-aminobenzoic acid 14801 or more sophisticated structures. A few examples (1-6) are shown in Scheme 28. Numerous cyclic turn mimetics have been developed in the past years and for details on this subject the reader is directed to Vol. E 22c, Section 12. To explore the rigidification introduced by nonnatural amino acids or equivalent structures into cyclic peptides, a careful NMR conformational analysis is required, since frequently the so-called p-turn mimetics do not enable such turns to be established, conversely other secondary structure elements may be induced.14811... 

The resulting e-aminocaproic acid hydrochloride is converted into the amino acid by means of a column containing Amberlite IR-4B resin (Note 2) ... 

Benzoyl-e-aminocaproic acid-bitter compound mixtures, tasting behavior, 33,34f... 

Nylon 6 is also a polyamide, but is made from the monomer e-caprolactam, which is a cyclic amide of e-aminocaproic acid. Heat opens the lactam ring to give the amino acid salt, which forms amide bonds with other molecules by eliminating water. 

Both e-aminocaproic acid and tranexamic acid may improve haemostasis by a combination of inhibition of fibrinolysis, reduced release of tPA, and preservation of platelet function. Tranexamic acid is more potent and has the same low toxicity as -aminocaproic acid and the latter is now seldom used and is no longer registered for clinical use in many countries. 

Aminobutane, AD 6 Aminobutanediolc acid, AC99 N-Aminobutyramide, AE99 e-Aminocaproic acid, A 115 [(2-Amino-2-carboxyethyl)th io]-... 

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