E2 Enzymes Dedicated to Ubiquitin-like Proteins UbLs

E2 Enzymes Dedicated to Ubiquitin-like Proteins (UbLs) 

The reader should consult earlier reviews [70, 94, 95] and other chapters in this volume for a detailed discussion of UbL biology and biochemistry. There are two important points for the current discussion. First, the conjugation cascades of UbLs differ from that of ubiquitin chiefly in terms of complexity - there is one conjugating enzyme per UbL, and many fewer E3s. Second, because modifier proteins (including ubiquitin) do not interact strongly with their dedicated E2s (Section 5.6.1), it is believed that El enzymes play the major role in matching E2s with the correct modifier protein (see Ref [96]). 

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