Dysidea avara

Muller, W. E. G., Bohm, M., Batel, R., Rosa, S. D., Tommonaro, G., Muller, I. M., and Schroder, H. C. (2000). Application of cell culture for the production of bioactive compounds from sponges Synthesis of avarol by primmorphs from Dysidea avara. J. Nat. Prod. 63,1077-1081. 

Thiofurodysinin (326), a furanosesquiterpene from Dysidea avara from Australia, was the first report of a sesquiterpene mercaptan from a sponge [296]. 

Dysidea avara from the Solomon Islands contained the melemeleones A (339) and B (340), which were identified by spectroscopic analyses [305]. They consist of a sesquiterpene linked to a quinone with an attached taurine residue [22]. 

From another Dysidea sponge species, Dysidea avara, the sesquiterpenes avarol, Fig. (9) and avarone, Fig. (10), which show a wide variety of biological activities, were first isolated. Both compounds are potent antileukemic agents in vitro and in vivo. They were determined to be neither direct mutagens nor premutagens, and they displayed antimutagenic activity... 

Muller, W. E. G., Diehl-Seifert, B., Sobel, C., Bechtold, A., Kljajic, Z., and Dorn, A., Sponge secondary metabolites biochemical and ultrastructural localization of the antimitotic agent avarol in Dysidea avara, J. Histochem. Cytochem., 34, 1687, 1986. 

Sponges produce furanosesquiterpenes of various skeletal types, such as furodysinin (118) from Dysidea herbacea and nakafuran-8 (119) from D. etheria, the latter of which is antifeeding. Similarly, mixed shikrmate-mevalonate metabolites are often encountered as sponge metabolites the first example is avarol (120), which was isolated from Dysidea avara. Several related compounds have been isolated from dictyoceratid... 

A. (1986) Sponge secondary metabolites biochemical and ultrastructural localization of the antimitotic agent avarol in Dysidea avara. J. Histochem. Cytochem. 34, 1687-1690. 

Uriz M. J., Turon, X., Gordi, J., and Tur, J. M. (1996) New light on the cell location of avarol within the sponge Dysidea avara (Dendroceratida). Cell Tissue Res 285,519-527. 

Dysidea avara [212,213] currently commercialised as a cream against skin disorder. 

W. E. G. Muller, R. K. Zahn, E. Eich Extraction and purification of avarone and avarol from Dysidea avara,Ger. Offen., DE 3621032 Al, 28th January 1988. 

A. (C21H30O2, Mr 314.47, cryst., mp. 148-150°C, [a]p +6.1°) and avarone (C21H28O2, Mr 312.45, oil, optically inactive) are components of the marine sponge Dysidea avara with interesting antileukemic and cytostatic activities they do not affect healthy cells. Both substances inhibit the replication of AIDS viruses. 

Cariello, L., M. De Nicola Giudici, and L. Zanetti Developmental Aberrations in Sea-Urchin Eggs Induced by Avarol and Two Cogeners. The Main Sesquiterpe-noid Hydroquinones from the Marine Sponge, Dysidea avara. Comp. Biochem. Physiol. 65C, 37 (1980). 

Bacillus vallismortis (C89) Sponge (Dysidea avara) Unidentified tube worm Neobacillamide A Not cytotoxic Yu et al., 2009... 

Yu, L.-L., U, Z.-Y., Peng, C.-S., Li, Z.-Y, and Guo, Y.-W. (2009) Neobacillamide A, a novel thiazolealkaloid from the marine bacterium Bacillus vallismortis C89, associated with South China Sea sponge Dysidea avara. Helv. Chim. Acta. 92,607-611. 

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