Dynamics of protein folding

TRIR methods have also found utility in the elucidation of reaction mechanisms involved in biological systems, most notably photosynthetic and respiratory proteins. In addition, TRIR spectroscopy has also been used to enhance our understanding of the dynamics of protein folding processes. ... 

Faisca PFN, da Gama MMT (2005) Native geometry and the dynamics of protein folding. Biophys. Chem. 115 169-175... 

To follow the dynamics of protein folding, the conformational changes of the protein must be measured as a function of time. Moreover, it would be advantageous to be able, simultaneously and independently, to detect the different conformers rather than to obtain a measured value that reflects the average state of all the conformers in solution. ESI-MS is suitable for this kind of a study. 

In the Section XI, we summarize the major points of this chapter. We will also propose future development of our strategy with application to systems with many degrees of freedom— for example, the dynamics of protein folding. We suggest that coarse graining of the phase-space strucmre may need to be incorporated to tackle such a problem. 

Proteins. The questions, What kinds of mechanisms carry a protein into an unique native state and What is the best reaction coordinate to describe the dynamics of protein folding have been among the most intriguing subjects over the past decades in biological physics [35,36]. The process of protein folding may be interpreted as a normal Brownian process of a few collective... 

Molecular models can considerably impact the chemical process industry. Obviously, numerous problems fall beyond the realm of conventional molecular simulation (see the example above on zeolitic membranes). Examples include dynamics of protein folding, diffusion through microporous membranes and human cells, formation of quantum dots in heteroepitaxial growth of semiconductors, and pattern formation on catalyst surfaces. 

See also Covalent Bonds vs Non-Covalent Forces, DNA, Secondary Structure (from Chapter 2), Dynamics of Protein Folding... 

See also a-Helix, / -Sheet, Factors Determining Secondary and Tertiary Structure, Thermodynamics of Protein Folding, Dynamics of Protein Folding, Covalent Modifications to Regulate Enzyme Activity (from Chapter 11). 

See also Dynamics of Protein Folding, Polypeptide Chain Folding, (from Chapter 27)... 

In summary, MS has enormous potential for the studies of dynamics of protein folding. Conventional sample preparation and ionization techniques have been optimized considering specifics of such measurements. It appears that rapid micromixers (tees, theta capillary emitters, dual emitters) used with ESI, on-line HDX in conjunction with bottom-up... 

DETERMINISTIC GLOBAL OPTIMIZATION AND AB INITIO APPROACHES FOR THE STRUCTURE PREDICTION OF POLYPEPTIDES, DYNAMICS OF PROTEIN FOLDING, AND PROTEIN-PROTEIN INTERACTIONS... 

Deterministic Global Optimization and Ab Initio Approaches FOR the Structure Prediction of Polypeptides, Dynamics of Protein Folding, and Protein-Protein Interactions 265... 

In the present discussion, the phenomenological aspects of the dynamics of protein folding are reported and only the kinetic studies are described. Nevertheless, the attempts to interpret the slow phase during the unfoldingfolding process, evinced in many kinetic studies (Baldwin, 1975), are included. Characterization of intermediary species are detailed in Chapter 8. 

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