Dynamic non-covalent chemistry

DCC Dynamic covalent chemistry or dynamic combinatorial chemistry DNCC Dynamic non-covalent chemistry... 

The synthesis of rotaxanes (and catenanes) carried out under kinetically controlled conditions has as a drawback the employment of an irreversible bond-forming final step, which may yield competitive or unwanted non-interlocked by-products. Methods allowing interlocking to occur in a thermodynamically controlled manner have therefore been developed, so that by-products can be recycled to afford the energetically, most favored, interlocked species, via reversible breakage/formation of covalent bonds ( dynamic covalent chemistry ) <2002AGE898>. 

A minimum requirement for a true enzyme mimic is a binding interaction between two molecules preliminary to the catalytic reaction, indicated by Michaelis-Menten kinetics. Intramolecular systems can support very rapid reactions because we can use synthesis to bring groups together into close and unavoidable proximity. But an enzyme must select and bind its substrate non-covalently in a dynamic equilibrium. The chemistry of... 

Since 1987, supramolecular chemistry has developed into a major field [1], New structures with novel properties have been created from existing molecules via non-covalent interactions, including hydrophobic interactions, electrostatic forces, H-bonding, van der Waals forces, etc. At the very beginning, supramolecular chemistry dealt with small molecules such as crown ethers and cryptands. Later, non-covalent interactions were applied to the field of macromolecules, yielding an important concept of a supramolecular polymer [2], Connected by non-covalent interactions, the dynamic supramolecular polymer fused the two fields of small organic molecules and macromolecules. The principle of supramolecular chemistry is central not only to chemical sciences but also to life and material sciences [3-7]. 

Nevertheless, self-assembling processes by nature rely on weak interactions and the isolation of chemically stable knots and links requires a final knotting step in which covalent bonds are formed. While irreversible reactions such as Williamson ether reactions" and ring closing methathesis are employed successfully to form knots and links, their template-directed syntheses have recently been enriched by the concept of dynamic covalent chemistry (DCC). DCC employs reversible covalent bond formation that allows equilibration of a system toward the most thermodynamically stable structures dictated by the sum of the non-covalent bonding interactions. 

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