Formulations dry powder inhalers

Crowder TM, Rosati JA, Schroeter JD, Hickey AJ, Martonen TB. Fundamental effects of particle morphology on lung delivery predictions of Stokes law and the particular relevance to dry powder inhaler formulation and development. Phanna Res 2002 19 239-245. 

Buckton G. Characterization of small changes in the physical properties of powders of significance for dry powder inhaler formulations. Adv Drug Delivery Rev 1997 26 17-27. 

Begat, P., Morton, D. A., Staniforth, J. N., and Price, R. (2004), The cohesive-adhesive balances in dry powder inhaler formulations I Direct quantification by atomic force microscopy, Pharm. Res., 21,1591-1597. 

El-Sabawi, D., Price, R., Edge, S., and Young, P. M. (2006), Novel temperature controlled surface dissolution of excipient particles for carrier based dry powder inhaler formulations, Drug Dev. Ind. Pharm., 32,243-251. 

Mackin, L.A. Rowley, G. Fletcher, E.J. An investigation of carrier particle type, electrostatic charge and relative humidity on in-vitro drug deposition from dry powder inhaler formulations. Pharm. Sci. 1979, 3, 583-586. 

Vanderbist F, Wery B, Moyano-Pavon I, Moes AJ. Optimization of a dry powder inhaler formulation of nacystelyn, a new mucoactive agent. / Pharm Pharmacol 1999 51(11) 1229-1234. 

Morton DA, Green M, Staniforth JN, Whittock A, Begat P, Price R, Young P. The study of force control additives in creating high-performance dry powder inhalation formulations. In Respiratory Drug Delivery VIII Dalby RN, Byron PR, Farr SJ, eds. Interpharm Press Tucson, AZ, 2002 763-766. 

Begat P, Morton DAV, Staniforth JN, et al. The cohesive-adhesive balances in dry powder inhaler formulations II influence on fine particle delivery characteristics. Pharm Res 2004 21(10) 1826-1833. 

In particular, the loose packing of particles promotes an open powder structure that is less adhesive and flows and disperses more readily. There is a strong correlation between the interaction parameters derived by IGC and the in vitro data that play an important role in the prediction of aerosol performance of dry powder inhalation formulations. Enhanced dispersibility is particularly important for DPI devices, where performance strongly depends on powder deaggregation at relatively low dispersion forces. Clearly, high turbulence is preferable for dispersion, but it inevitably leads to high pressure differentials, which may prevent many devices from functioning correctly. In addition, low dispersion forces for supercritically produced... 

Wang, Y., Kho, K., Cheow, W.S., Hadinoto, K. A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid-polymer hybrid nanoparticles. Int. J. Pharm. 2012, 424 (1-2), 98-106. 

H.H.Y. Tong, B.Y. Shekunov, P. York, A.H.L. Chow, Predicting the aerosol performance of dry powder inhalation formulations by interparticulate interaction analysis using inverse gas chromatography. Journal of Pharmaceutical Sciences, 95,228-233,2006. 

P. Begat, R. Price, H. Harris, D.A.V. Morton, J.N. Staniforth, The influence of force control agents on the cohesive-adhesive balance in dry powder inhaler formulations, KONA Powder Particle Journal, 23,109-1231,2005. 

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