Drug substance solid dosage forms

Drug Product- Solid Dosage Form or Liquid Containing Undissolved Drug Substance... 

Drug product - solid dosage form or liquid containing undissolved drug substance... 

Incompatibilities have also been observed in solid dosage forms. A typical tablet contain binders, disin-tegrants, lubricants and fillers. Compatibility screening for a new drug should consider two or more excipients from each class. Serajuddin et al. have developed a drug-excipient compatibility screening model to predict interactions of drug substances with excipients [49],... 

The ability to form complexes with such a large number of substances is a special feature of polyvinylpyrrolidone (Section 2.2.7). The complexes formed are almost always soluble and are stable only in an acid medium. This property can be used to increase the solubility of drugs in liquid dosage forms, as in the case of povidone-iodine. In solid dosage forms, the ability to form complexes is used to increase bioavailability. A reduction in the local toxicity of certain drugs can also be achieved by complexation with povidone. A special use for the complexation properties lies in the stabilization of proteins and enzymes in diagnostics. 

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