Drug solubilization emulsifiers

Properties Crystals m.p. 39.5-40.5 C nonionic Toxicology TSCA listed Uses Solubilizer, emulsifier, emollient for pharmaceuticals, cosmetics carrier, vehicle for drugs in capsules solvent, solubilizer for active ingreds. antistat for syn. materials softener for chewing gum base defoamerin food-contact paper/paperboard in food-contact textiles... 

Definition Complex mixture formed from the transesterification of olive oil and PEG-6 Properties Oil nonionic Uses Emollient, solubilizer, emulsifier for cosmetics, pharmaceuticals amphiphilic agent improving drug delivery Features Hydrophilic... 

Continuous aqueous phase emulsion polymerization is one of the most widely used procedures to make nanoparticles for drug delivery purposes, especially those prepared from the alkylcyanoacrylate monomers. An oil-in-water emulsion system is employed where the monomer is emulsified in a continuous aqueous phase containing soluble initiator and surfactant [39, 40]. Under these conditions, the monomer is partly solubilized in micelles (5-10 nm), emulsified as large... 

Uses. Anticorrosive agent chemical intermediate for the production of emulsifiers, detergents, solubilizers, cosmetics, drugs, and textile finishing agents... 

In principle, in the preparation of medicated nanoemulsions, the drug is initially solubilized or dispersed together with an emulsifier in suitable single oil or oil mixtures by means of slight... 

Solubilization of hydrolyzable drugs in micelles retards the rate of hydrolysis since the nonpolar chains, containing the hydrolyzable bonds, are situated in the deep core of a micelle. Anionic micelles repel the incoming OH and hold the H+ in the vicinity of the surface avoiding further penetration of H+ into the micelle. If micelles are formed by self-emulsifying drugs such as penicillin G, they are reportedly more stable than their simple solutions under the same conditions of pH and ionic strength. 

The irradiation of micellar solutions effects the phase behavior and the critical micelle concentration (CMC). Because radiation sterilization of biopharmaceutical products is a common routine it is important to investigate the influence of radiation on surfactants that are widely used in the pharmaceutical industry for formulations as wetting agents, emulsifiers, or solubilizers. In particular, in drug formulations... 

Formulation studies are performed to develop a suitable vehicle to solubilize the drug for administration to patients, generally by intravenous injection or infusion in the case of cancer. The low solubility of many natural products in water poses considerable problems, but these can be overcome by use of co-solvents or emulsifying agents (surfactants) such as Cremophore EL (polyoxyethylated castor oil). 

The phospholipids are widely found in biological membranes and can be used as emulsifiers especially for intravenous fat emulsions, and as a key component of liposomes. The elucidation of factors governing the solubilization of drugs in phospholipid dispersions can provide some clues as to the biological role of interactions with lipid systems in vivo. " Phospholipids have been discussed above and in reference in the context of liposomes. 

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