Drug rational strategy

Fig. 1.8). It is currently in clinical trial. Other examples of the commercial utility of QSAR include the development of metamitron and bromobutide (250).In most of these examples, QSAR was used in combination with other rational drug-design strategies, which is a useful and generally fruitful approach. 

Rational drug use strategy and monitoring through national strategies. 

Emphasizing product competition over price competition is a rational strategy for companies operating in a market that is not very sensitive to price differentials among similar compounds. If prescribing physicians will not be swayed by lower prices, it would be foolhardy for firms to set prices for their products much lower than those of competitors. Unless or until the demand for prescription drugs becomes more price sensitive, the benefits of the competitive R D on prices will not be felt. 

Figure 3.22 The penicillin molecule interferes with the action of bacteria (and therefore of infections) by mimicking the structure of D-ala-D-ala involved in the production of bacterial cell walls in cell division. This is a rationalisation after the event, namely the discovery of the action of penicillin by chance by Alexander Fleming. By contrast modern rational drug design strategies involve using the knowledge of the structure of receptor sites. From Helliwell (1977b) reproduced with permission of New Scientist.

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