Drug proteomics applications

Quantitation and qualification of large molecules follow similar principles as procedures for small molecules but involve different foci and approaches. The quantitation of proteins and peptides includes relative and absolute amount evaluations. Most proteomic applications in drug discovery are concerned with relative abundances of proteins. 

Steiner S, Wiltzman FW. Proteomics applications and opportunities in preclinical drug development. Electrophoresis 2000 21 2099-104. 

Rapid advances have been made in proteomic research, with growing success in protein quantitation utilizing MS technologies [74-76]. The quantitative tools from proteomics and other analytical innovations have great potential to be translated to macromolecule drug bioanalytical applications, and are discussed in the following sections. 

The study of cellular protein expression by proteomics has relied on technologies that first appeared in the 1970s and have been continuously improved. In combination with advanced bioinformatics and large databases, proteomics now provide a powerful tool for basic research, clinical diagnostics, and drug development applications. 

Walgren JL, Thompson DC. Application of proteomic technologies in the drug development process. Toxicol Lett 2004 149 377-85. 

Jain, K. 2001. Proteomics new technologies and their applications. Drug Discovery Today 6(9), 457-459. 

Whereas mass spectrometry in proteomics was discussed in an earlier volume of this series (Volume 28, M. Hamacher et al. 2006, Proteomics in Drug Research, WUey-VCH, Weinheim), the current monograph focuses on mass spectrometry applications in lead discovery and optimization. As discussed in more detail in the foreword of the volume editors, the chapters provide a comprehensive over-... 

Jeffery DA, Bogyo M. Chemical proteomics and its application to drug discovery. Curr Opin Biotechnol 2003 14 87-95. 

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