Drug/protein release systems

The design of new injectable dosage forms for the administration of peptide or protein drugs for the realization of the targeted release systems in the nanoscale range requires three fundamental ingredients ... 

Cappello, J., Crissman, J. W., Crissman, M., Ferrari, F. A., Textor, G., Wallis, O., Whidedge, J. R., Zhou, X., Burman, D., Aukerman, L., and Stedronsky, E. R. (1998). In-situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs. /. Control. Release 53, 105-117. 

Polyanhydrides are promising as biomaterials because they possess a unique combination of properties that include hydrolytically labile backbone, hydrophobic bulk, and chemistry that can be easily combined with other functional groups to design novel materials. These materials are primarily surface-erodible and offer the potential to stabilize protein drugs and sustain release from days to months. The microstructure characteristics of copolymer systems can be exploited to tailor drug release profiles. The versatility of polyanhydride chemistry promises a new class of drug release systems for specific applications. 

Drug Delivery. Philadelphia Taylor Francis. ISSN 1071-7544. Covers basic research, development, and application principles of drug delivery and targeting at molecular, cellular, and higher levels. Topics covered include all delivery systems and modes of entry, such as controlled release systems microcapsules, liposomes, vesicles, and macromolecular conjugates antibody targeting and protein/peptide delivery. Peer-reviewed. 

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