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Drug metabolism discipline

In 2003 he was appointed Head of Drug Metabolism and Pharmacokinetics in Paris working simulataneously in France and Germany. The main objective of his work is an intensive knowledge transfer from early parts of the value chain ( Research ) to the late stages ( Development ) and vice versa across the different disciplines. [Pg.876]

In addition to the scientific disciplines, e.g., pharmacology, chemistry, toxicology, drug metabolism and pharmacokinetics, and biopharmaceutics, involved on the discovery team, the preclinical drug development team has a number of new players. These new players include, among others ... [Pg.4]

Six scientific disciplines are involved in the developability characterization of a lead discovery candidate. As shown in Figure 4, these disciplines are in vivo pharmacology, bioanalytical method development, nonclinical formulation assessment, animal pharmacokinetics, drug metabolism, and toxicology. The following sections discuss each of these scientific disciplines in more detail. [Pg.24]

Other involved departments/disciplines that are equally important as the above groups include Analytical Chemistry, Biochemistry, Biopharmaceutics/ Pharmacokinetics/Drug Metabolism, Chemical Pilot Plant, Experimental Engineering, Packaging Development, and Statistics. Additional significant contributors include Purchasing and Quality Assurance/ Documentation. [Pg.1370]

Interplay of Synthetic Chemistry and Advanced Pharmacology Similar to the demands prompted by rigorous analytical chemistry, the need for syntheses of both anticipated metabolites and experimentally derived metabolite possibilities serves to maintain the complimentary relationship between medicinal chemistry and the biologically oriented disciplines working in the field of drug metabolism and toxicology. This is a valuable relationship where the medicinal chemist... [Pg.516]

The editors have chosen topics from both important therapeutic areas and from work that advances the discipline of medicinal chemistry. For example, cancer, metabolic syndrome and Alzheimer s disease are fields in which academia and industry are heavily invested to discover new drugs because of their considerable unmet medical need. The editors have therefore prioritized covering new developments in medicinal chemistry in these fields. In addition, important advances in the discipline, such as fragment-based drug design and other aspects of new lead-seeking approaches, are also planned for early volumes in this series. Each volume thus offers a unique opportunity to capture the most up-to-date perspective in an area of medicinal chemistry. [Pg.224]

Abstract Proteomics, the comprehensive analysis of the protein complement of the genome of an organism, is becoming an increasingly important discipline for the identification of disease targets. In addition, the effects of drug treatment and metabolism can now be studied on the protein level in a comprehensive manner. [Pg.547]


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