Drug discovery research understanding

Houck, K.A. and Kavlock, R.J. (2008) Understanding mechanisms of toxicity insights from drug discovery research. Toxicology and Applied Pharmacology,... 

Houck KA, Kavlock RJ. Understanding mechanisms of toxicity Insights from drug discovery research. Toxicol Appl Pharmacol. 2008 227(2) 163-178. 

In this chapter, different VS studies and their results are discussed and it is attempted to critically evaluate the opportunities and limitations of VS, with a particular focus on its practical relevance and value. A general perspective upfront As proponents and developers of computational methods and also as VS practitioners, our view of the VS field should not come across as intentionally negative. Rather, we understand the critique as a plea for this field. However, we are convinced that it will be essential to raise the scientific standards of VS and the awareness of its limitations in order to provide a foundation for further growth of the field and for higher impact on drug discovery research. 

In our courses, we cover some aspects of all topics in this book. This is appropriate for students who become involved in drug discovery and research and development. The chapters are comprehensive in covering the diversity of applications of each subject. Each section of this book could be a monograph on its own. However, with the material presented in these chapters a scientist would be able to enter the entire literature and understand current research papers. 

From the point of view of drug discovery, ligands acting at the G-protein-coupled receptors have resulted in most successful drug candidates.Some of the examples illustrating how receptor research has led to more selective drugs and enhanced our understanding of the roles played by various receptor sub-types in disease processes are mentioned below. Early examples of different receptor subtypes... 

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