Drug design metabolism

Smith, D. A., Van de Waterbeemd, H., Walker, D. K. Pharmacokinetics and Metabolism in Drug Design, 2nd edn. Methods and Principles in Medicinal Chemistry), Wiley-VCH, Weinheim, 2006. 

The editors have chosen topics from both important therapeutic areas and from work that advances the discipline of medicinal chemistry. For example, cancer, metabolic syndrome and Alzheimer s disease are fields in which academia and industry are heavily invested to discover new drugs because of their considerable unmet medical need. The editors have therefore prioritized covering new developments in medicinal chemistry in these fields. In addition, important advances in the discipline, such as fragment-based drug design and other aspects of new lead-seeking approaches, are also planned for early volumes in this series. Each volume thus offers a unique opportunity to capture the most up-to-date perspective in an area of medicinal chemistry. 

Drugs-Design. 2. Drugs-Metabolism. 3. Drug development. 

Apart from patient-specific parameters, external factors - most importantly the concomitant uptake of certain other chemicals present in diet, environment and especially other drugs - influence drug actions. Possible effects are manifold and can affect all stages of pharmacokinetic and pharmacodynamic processes in the body. Also direct interaction and inactivation of concomitantly administered substances are possible. Drug-drug interactions via modulation of metabolism present a very hot topic in pharmaceutical research and drug design. 

Grossman, S.J., Overview drug metabolism in the modem pharmaceutical industry. In Drug Metabolism in Drug Design and Development, Zhang, D., Zhu, M. and Humphreys, W.G. (eds). J. Wiley Sons, Inc., 2008, pp. 3-13. 

Pharmacokinetics and Metabolism in Drug Design 5 Edited by D. A. Smith, H. van de Waterbeemd, D. K. Walker, R. Mannhold, H. Kubinyi, H. Timmerman I... 

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