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Metabolic stability, drug design

Captopril was announced in 1977 by the Squibb group led by Ondetti and Cushman (95,96), and the history of its design has been extensively reviewed (for example in 72,73, 97-102). Attempts to build metabolic stability into the peptide BPP5a were not successful, nor was a viable nonpeptide lead discovered in the Squibb sample collection (101). Captopril instead is one of the landmark achievements of rational drug design. [Pg.22]

The word drugability is often used to cover all aspects of a molecule beyond initial potency. A potential drug compound must overcome many challenges in order to be a successful therapeutic. Critical components of drug design include absorption, permeation, distribution, metabolism, stability, specificity (does it do more than... [Pg.105]

See other pages where Metabolic stability, drug design is mentioned: [Pg.187]    [Pg.308]    [Pg.460]    [Pg.419]    [Pg.126]    [Pg.421]    [Pg.84]    [Pg.55]    [Pg.449]    [Pg.666]    [Pg.738]    [Pg.8]    [Pg.10]    [Pg.23]    [Pg.559]    [Pg.81]    [Pg.118]    [Pg.311]    [Pg.303]    [Pg.249]    [Pg.269]    [Pg.1513]    [Pg.35]    [Pg.214]    [Pg.513]    [Pg.351]    [Pg.428]    [Pg.573]    [Pg.97]    [Pg.251]    [Pg.1256]    [Pg.2263]    [Pg.2505]    [Pg.2526]    [Pg.108]    [Pg.117]    [Pg.128]    [Pg.133]    [Pg.117]    [Pg.186]    [Pg.126]    [Pg.11]    [Pg.373]    [Pg.402]    [Pg.285]    [Pg.28]    [Pg.483]   
See also in sourсe #XX -- [ Pg.100 , Pg.101 ]



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