Drug delivery systems specialized

Martin F. J. (1989). Pharmaceutical manufacturing of liposomes, in Specialized Drug Delivery Systems Manufacturing and Production Technology (P. Tyle, ed.), Marcel Dekker, New York. In Press. 

It is evident that numerous conditions exist that separate the elderly from young adults. Moreover, some of these conditions have a substantial impact on the use of drug-delivery systems by elderly patients. With the ever-increasing proportion of elderly patients in our population, it is surprising that relatively few special products are marketed to accommodate the needs of these patients in terms of drug-delivery design. 

Specialized Drug Delivery Systems Manufacturing and Production Technology, edited by Praveen Tyle... 

SH Gehrke, PI Lee. Hydrogels for drug delivery. In P Tyle, ed. Specialized Drug Delivery Systems, Manufacturing and Production Technology. New York Marcel Dekker, 1990, pp 333-392. 

Drug-delivery systems are essentially specialized dosage forms developed to overcome the limitations of conventional dosage forms, such as simple tablets, capsules, injectable solutions, etc. Some of the reasons behind the development of oral DDSs are listed below ... 

Noncovalent interactions play a special role in synthetic procedures used to assemble various types of supramolecular species. These syntheses rely on the stabilization provided by non-covalent interactions between recognition sites incorporated within precursors. Various types of non-covalent interactions can be used as a recognition motif utilized to guide the synthesis.Targeted synthesis of macro- and supramolecular structures of various sizes, shapes, and functionality has now become possible. Supramolecular chemistry offers incredible applications in various fields such as medicinal chemistry (drug delivery systems),host-guest chemistry,catalysis,and molecular electronics. ... 

Significant developments have occurred in recent years in the fields of biopolymers and biomaterials. New synthetic materials have been synthesized and tested for a variety of biomedical and related applications from linings for artifical hearts to artifical pancreas devices and from intraocular lenses to drug delivery systems. Of particular interest in the future is the development of intelligent polymers or materials with special functional groups that can be used either for specialty medical applications or as templates or scaffolds for tissue regeneration. 

Solid oral dosage forms containing new chemical entities (NCEs) are commonly formulated into tablets or capsules as their first market image formulation. Subsequent drug product line extension development on these NCEs may evaluate more specialized drug delivery systems. Dissolution testing of standard oral tablets or capsules will commonly utilize the paddle or basket apparatus. In this chapter we focus primarily on the development and subsequent validation of dissolution testing methods that use these two devices. 

Excipients manufacture The manufacture of novel excipients may be provided in an application or supporting DMF. Typically these excipients are noncompendial and are used in specialized dosage forms and drug delivery systems. CDER chemists are responsible for the scientific reviews and evaluation of the records and data associated with the manufacture of these novel excipients. The review will include starting materials, key intermediates, reagents, and solvents. cGMP inspections by the Field usually will be performed on request from CDER. 

More recently, we have seen the development of drug delivery systems as a specialized sector in the pharmaceutical industry. This whole concept is based on the interaction of excipients with the API and manufacturing process, and sometimes with other excipients, to produce a formulation of a medicinal product that meets a particular performance specification. 

Modern Pharmaceutics Second Edition, Revised and Expanded, edited by Gilbert S. Banker and Christopher T. Rhodes Specialized Drug Delivery Systems Manufacturing and Production Technology, edited by Praveen Tyle... 

Gehrke SH, Lee PI (1990) In Tyle P (ed) Specialized drug delivery systems manufacturing and production technology. Marcel Dekker, New York, p 333... 

In general, the blood-brain barrier (BBB) is only permeable to lipophilic molecules of molecular weight <600 Da, while even small water-soluble molecules generally cannot be transported [21]. This would preclude the direct delivery of ASO to the brain from the systemic circulation without the assistance of specialized drug delivery systems. 

Specialized drug delivery systems constitute a relatively recent addition to the field of pharmaceutical technology. Up until the 1940s conventional dosage forms essentially comprised ... 

Developing an appropriate drug delivery system for a given drug can completely alter the drug s unfavorable properties, such as improve its effectiveness or reduce its side effects. Dry powder delivery systems such as microspheres are of special interest. In the last two decades they have been extensively studied with respect to nasal delivery and a considerable number of studies have been reported on that subject [3,23],... 

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