Drug delivery hydrogel polymers

Key words photo-responsive polymer, phototriggers, drug delivery, hydrogel, polymer actuators. 

Sastre, R.L. Blanco, M.D. Gomez, C. Socorro, J.M. Teijon, J.M. Cytarabine trapping in poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels drug delivery studies. Polym. Int. 1999, 48, 843-850. 

C. Liu, Y. Chen, J. Chen, Synthesis and characteristics of pH-sen-sitive semi-interpenetrating polymer network hydrogels based on konjac glucomannan and poly (aspartic acid) for in vitro drug delivery, Carbohydr. Polym. 79 (2010) 500-506. 

Zhang Z, Chen L, Zhao CW, Bai YY, Deng MX, Shan HL, Zhuang XL, Chen XS, Jing XB (2011) Thermo- and pH-responsive HPC-g-AA/AA hydrogels Pot controlled drug delivery applications. Polymer 52 676-682... 

Huang YJ, Liu MZ, Gong QY, et al. A novel magnetic triple-responsive composite semi-lPN hydrogels for targeted and controlled drug delivery. Eur Polym J October 2012 48 1734-44. 

M.EA. Taleb, Radiation synthesis of polyampholytic and reversible pH-responsive hydrogel and its apphcation as drug delivery system. Polymer Bulletin, 61 (3), 341-351,2008. 

H. Kono, F. Otaka, and M. Ozaki, Preparation and characterization of guar gum hydrogels as carrier materials for controlled protein drug delivery, Carbohydr. Polym., Ill, 830-840, 2014. 

Key words enzyme-responsive materials (ERMs), regenerative medicine and drug delivery applications, polymer hydrogels and scaffolds, supramolecular particles and self-assembly polymer particles. 

Chen, J., Jo, S., and Park, K. (1995) Polysaccharide hydrogels for protein drug delivery. Carbohydr. Polym., 28,... 

M.R. Saboktakin, R. Tabatabaie, A. Maharramov, and M.A. Ramazanov, Synthesis and characterization of superparamagnetic chitosan-dextran sulfate hydrogels as nano carriers for colon-specific drug delivery, Carbohydr. Polym. 81 372-376,2010. 

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Zhtmg, Z., Chen, L., Deng, M., et al. Biodegradable thermo- and pH-responsive hydrogels for oral drug delivery. J. Polym. Sd. Part Polym. Chem. 49, 2941—2951 (2011). doi 10.1002 /pola.24730... 

El-Sherif H, El-Masry M, Abou Taleb MF [2010], pH-Sensitive hydrogels based on bovine serum albumin for anticancer drug delivery. ] Appl Polym Sci, 115,2050-2059. 

Poly[(4-carboxylatophenoxy)(methoxyethoxyethoxy)phosphazene] copolymers of variable compositions were synthesized by Allcock [645] in 1996. These polymers were found to be soluble in alkaline solutions. When crosslinked (by y-rays or by addition of CaCl2 to the polymer solution) the resulting hydrogels were found able to contract or expand as a function of the pH of the solution and their utilization as pH-responsive materials for drug delivery systems could be envisaged. 

In the gastrointestinal tract, a mucoadhesive drug delivery system provides advantages in prolonging the residence time of devices. The use of pH-sensitive bioadhesive polymers has been proposed [26], An extensive review of pH-sensi-tive hydrogels is given by Brpndsted and Kopecek [27],... 

Another class of environmentally sensitive materials that are being targeted for use in drug delivery applications is thermally sensitive polymers. This type of hydrogel exhibits temperature-sensitive swelling behavior... 

In the last few years there have been new creative methods of preparation of novel hydrophilic polymers and hydrogels that may represent the future in drug delivery applications. The focus in these studies has been the development of polymeric structures with precise molecular architectures. Stupp et al. (1997) synthesized self-assembled triblock copolymer, nanostructures that may have very promising applications in controlled drug delivery. Novel biodegradable polymers, such as polyrotaxanes, have been developed that have particularly exciting molecular assemblies for drug delivery (Ooya and Yui, 1997). 

Nabeshima, Y., Ding, Z. L., Chen, G. H., Hoffman, A. S., Taira, H., Kataoka, K., and Tsuruta, T., Slow release of heparin from a hydrogel made from polyamine chains to a temperature-sensitive polymer backbone, in Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems (N. Ogata, et al., Eds.), pp. 315-316. Springer, Tokyo (1996). 

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