Drug delivery devices infusion

Controlled-rate infusion devices, as well as feedback-regulated drug delivery devices, have the potential to improve drug safety and efficacy. With advancement in computer technology and miniaturization of precision motors, highly compact computer-controlled infusion pumps are now available for insulin delivery. These pumps, weighing about 3 to 4 ounces, can be... 

Microminiature drug delivery device. This is the heart of the implanted medication systems. The drug delivery device often consists of a diaphragm-operated infusion pump that supplies drug at a constant predetermined rate to the body. The pump is connected to the drug reservoir, which, in some cases, may be recharged when exhausted. Today, the available electronic components are so miniature that they can be implanted comfortably even in newborn babies. The pump can be programmed for a constant or variable basal infusion of medication with a repetitive period of from 1 hour to 60 days. By far the most frequently used basal period is 24 hours. A period of 28 days is available, particularly for the infusion of sex hormones to mimic the female menstrual cycle. 

Several technologies are currently under investigation for the development of new drug delivery devices that can achieve chronotherapy, specifically, iontophoresis, infusion pumps, and sonophoresis (96). 

UV acrylics are used to assemble injectors, infusion sets, pressure transducers, drug delivery devices, intravenous sets, oxygenators, cardiotomy reservoirs, blood heat exchangers, hearing aids, anaesthesia masks, and blood filters. 

Drug delivery pump and/or catheter infusion pump for implantation iontophor-eses device. 

The use of specific intravenous (FV) delivery devices also can cause ADRs. For instance, use of plastic infusion sets for IV administration of nitroglycerin has resulted in subtherapeutic effects due to diffusion of the drug into the plastic tubes. ... 

Transdermal delivery is a noninvasive intravenous infusion of drug to maintain efficacious drug levels in the body for predictable and extended duration of activity. Diffusion-controlled transdermal systems are designed to deliver the therapeutic agent at a controlled rate from the device to and through the skin into the systemic circulation. This route of administration avoids unwanted presystemic metabolism (first-pass effect) in the GI tract and the liver. Patient satisfaction has been realized through decreased... 

The infusion device described in this report can be fabricated in a few hours with materials usually available in a laboratory. For high flow, the aligned nylon fibre flow moderator can be used. When microvolume delivery is required, the use of the hollow fibre flow moderator can be considered. As for the infusion enclosures, the transparent material was specially chosen to allow visualization of the internal contents of the drug solution bag, which is always inspected at regualr intervals during use for the presence of particulate suspension or air bubbles that may develop and be harmful. 

The delivery of freeze-dried preparations can be performed by different routes oral, nasal, anal, pulmonary, transdermal and parenteral. Of these routes, some do not require any treatment of the drug before it is administered, e.g. in the form of powders or tablets or in inhaling devices. For parenteral administration, however, whether by injection or infusion, the freeze-dried cake must be returned to a liquid state, a process referred to as reconstitution . The main vehicle will normally consist of water for injection or a solution, the concentration of which will establish isotonicity. The time required for the complete dissolution of the cake may in some cases be critical and should therefore be known. 

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