Drug combination preparation

The same may hold true for the different stages in endothelial cell activation during flare-ups in chronic inflammatory disorders. Therefore, the use of a combination of different drug targeting preparations aimed at disease stage-specific epitopes is likely to be a prerequisite for targeting endothelial cells at various stages of activation. 

Hong, N. D., J. W. Kim, B. W. Kim, and J. G. Shon. Studies on the efficacy of the combined preparation of crude drugs. 6. Effect of Saengkankunbi-tang on activities of the liver enzyme, protein contents and the excretory action of bile juice in the serum of CCL4-intoxicated rabbits. Korean J Pharmacog 1982 13 33-38. 

Z0338 Hong, N. D., I. K. Chang, N. J. Kim, and I. S. Lee. Studies on the efficacy of combined preparations of crude drug (XXXIX). Effects of Hyangsayangwee-Tang on the stomach and intestinal disorder. Korean J Pharmacog 1989 20(3) 188-195. 

Geriatric Considerations - Summary Levodopa is a precursor to dopamine and is converted to dopamine in the CNS. Carbidopa decreases peripheral conversion and increases CNS concentrations of levodopa. While sustained-release forms may be helpful in decreasing the wearing-off of levodopa effectiveness, there maybe little advantage over immediate-release preparations. This drug combination is often used as initial therapy for Parkinson s disease. 

It should be realized, however, that therapeutic interference with only one cell type may not be enough to treat liver cirrhosis, because all hepatic cell types contribute to some extent to the development of the disease. Therefore, a combination of drug-targeting preparations to stellate cells, KC, endothelial cells, and/ or hepatocytes might improve the pharmacological therapies and compete with the liver transplantation technique. In addition to therapeutic applications, modified albumins may also be used for diagnostic purposes (an issue that will be addressed in section VI.C.4). 

Acetaminophen, sold under the trade name Tylenol, is a widely used analgesic and antipyretic that is an over-the-counter drug. Combined with codeine it is one of the top five prescription drugs. Acetaminophen is prepared by treating p-aminophenol with a mixture of glacial acetic acid and acetic anhydride. 

If an overdose of paracetamol combined with other drugs is taken, the situation may be very different. For example, the combined preparation Distalgesic contains not only paracetamol but also a drug called... 

The generic name, the standard being the WHO International Non-proprietary Name, is the first choice of the EMBASE indexers and for combination preparations the brand name is preferred. However, EMBASE allows drugs to be indexed under numerous names, more so than MEDLINE, and even includes the name of the manufacturer if it is in the original article. EMBASE concentrates more on the pharmacological and toxicological aspects of the biomedical literature than MEDLINE. 

Nevertheless, monolithic microspheres can be made to release drug at an approximately constant rate. " The core loading of these microspheres may be increased to create structures similar to those of reservoir microcapsules. An optimum combination of particle sizes (a size distribution), may be prepared to achieve a constant rate of drug release. Preparing microspheres with an erodible polymer in such a way that maximum erosion occurs in conjunction with minimum diffusion may establish a constant release rate. Although the principles described here appear simple, they are difficult to utilize because of their dependence on a number of factors, each of which can complicate the process. 

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