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Drug carriers, biodistribution

Kissel, M., P. Peschke, V. Subr, K. Ulbrich, J. Schuhmacher, J. Debus and E. Friedrich, 2001, Synthetic macromolecular drug carriers biodistribution ofpoly[(N-2-hydroxypropyljmethacrylamide] copolymers and their accumulation in solid rat tumors. PDA JPharm Sci Technol 55 191-201. [Pg.21]

In terms of biodistribution, Zhang et al. (1997) were not able to demonstrate any difference between the biodistribution of paclitaxel loaded into MePEGQLLA micelles versus paclitaxel solubilized in Cremophor EL (a conventional surfactant). These two formulations also showed similar in vitro distribution between the lipoprotein and lipoprotein-deLcient fraction of plasma (Ramaswamy et al., 1997). As for other drug carriers, plasma half-life and uptake of polymeric micelles by the MPS depend on the molecular weight (Kwon et al., 1994) and density of the hydrophilic shell (Hagan et al., 1996). [Pg.335]

Chemotherapy refers to drug administration with highly serious side effects, such as nausea, hand and foot rashes, mouth sores, and increased risk of infection, easy bruising, and so on. Therefore, liposomal carriers have been used in order to improve the drug s biodistribution and protect the patient from those side effects. The main anticancer drugs used to treat ovarian cancer are carboplatin and cisplatin, paclitaxel, topotecan, and lurtotecan. PEGylated liposomal doxorubicin has been approved as a regimen for patients with metastatic ovarian cancer refractory to both paclitaxel and platinum based-therapy [449],... [Pg.503]

Another important feature to consider in order to improve the effectiveness of controlled release is the shape control, and some recent works showed the effect of particle shape on drug carrier or functional food performance because of its influence on tissue biodistribution and endocytic... [Pg.371]

Choi, K.Y., et al. 2009. Self-assembled hyaluronic acid nanoparticles as a potential drug carrier for cancer therapy synthesis, characterization, and in vivo biodistribution. Journal of Materials Chemistry 19(24) 4102 107. [Pg.20]

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See also in sourсe #XX -- [ Pg.74 ]



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