Drug absorption models

Camenisch, G., Van de Waterbeemd, H Folkers, G. Review of theoretical passive drug absorption models historical background, recent development and limitations. Pharm. Acta. Helv. 1996, 73, 309-327. 

H Lennernas. Human jejunal effective permeability and its correlation with preclini-cal drug absorption models. J Pharm Pharmacol 49 627-638, 1997. 

Wikman, A., Karlsson, J., Carlstedt, I., Artursson, P., A drug absorption model based on the mucus layer producing human intestinal goblet cell line HT29-H, Pharm. Res. 1993, 30, 843-852. 

Lennernas H (1997) Human Jejunal Effective Permeability and Its Correlation with Preclinical Drug Absorption Models. J Pharm Pharmacol 49 pp 627-638. 

Correlation Between Nasal Drug Absorption Models... 

Bermejo M, Avdeef A, Ruiz A et al. (2004) PAMPA-a drug absorption model 7. Comparing rat in situ, Caco-2 and PAMPA permeability of flouroquinolones. Eur J Pharm Sci 21 429M41... 

Osiecka, I. Porter, P.A. Borchardt, R.T. Fix, J.A. Gardner, C.R. In vitro drug absorption models. I. Brush border membrane vesicles, isolated mucosal cells and everted intestinal rings characterization and salicylate accumulation. Pharm. Res. 1985, 2 (6), 284—292. 

PA Porter, I Osiecka, RT Borchaidt, JA Fix, L Frost, CR Gardner. In vitro drug absorption models II salicylate, cefoxitin, a-methyl dopa, and theophylline uptake in cells and rings correlation with in vivo bioavailability. Pharm Res 2 293—298,1985. 

A wide array of drug absorption models and powerful computational facilities are available to population and traditional PK modelers, yet adequate absorption models are seldom available, presented in the literature, or estimated during drug development. The factor limiting the development of adequate absorption models is... 

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