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Drift, HPLC detector response

An ELSD converts the HPLC eluent into a particle stream and measures the scattered radiation. It offers universal detection for nonvolatile or semivolatile compounds and has higher sensitivity than the RI detector (in the low ng range) in addition to being compatible with gradient analysis. ELSD is routinely used in combinatorial screening. Response factors are less variable than that of other detectors. An ELSD consists of a nebulizer equipped with a constant temperature drift tube where a counter-current of heated air or nitrogen reduces the HPLC eluent into a fine stream of analyte particles. A laser or a polychromatic beam intersects the particle stream, and the scattered radiation is amplified by a photomultiplier. Manufacturers include Alltech, Polymer Laboratories, Shimadzu, Waters, Sedere, and ESA. [Pg.512]

Typical Response Peaks. Figure 2 shows some typical response peaks for the HPLC separation of the saturates and aromatics in a typical vacuum gas oil. The curve in the upper portion of the figure is the response for the sample using the RI detector. After the saturates peak appeared, the backflush valve was switched and the attenuation changed as indicated in the figure. The peaks were very sharp and symmetrical and appeared in less than 10-min lapsed time from the point of injection. Base line drift was minimal and the areas of the response peaks were obtained with a ball and disc integrator on the strip chart recorder. [Pg.297]


See other pages where Drift, HPLC detector response is mentioned: [Pg.72]    [Pg.1433]    [Pg.294]    [Pg.13]    [Pg.1041]    [Pg.1361]    [Pg.19]    [Pg.82]    [Pg.27]    [Pg.33]    [Pg.84]   
See also in sourсe #XX -- [ Pg.23 , Pg.24 ]

See also in sourсe #XX -- [ Pg.23 , Pg.24 ]




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