Drag disposition

Pharmacokinetic model for analyzing drag disposition following direct intratumoral 391 injection... 

Kearns GL, Abdel-Rahman SM, Alander SW, et al. Developmental pharmacology—drag disposition, action, and therapy in infants and children. N Engl J Med 2003 349 1157-1167. 

Mayersohn M. Drag disposition in the elderly. In Penta FB, ed. Pharmacy Practice for the Geriatric Patient. Alexandria, VA American Association of Colleges of Pharmacy, 1986 9.5-9.11. 

Issues include altered drag disposition/metabolism and the need for a tier assessment of safety to include knowledge on... 

Kim, R.B. (2003) Organic anion-transporting polypeptide (OATP) transporter family and drag disposition. European Journal of Clinical Investigation, 33 (Suppl 2), 1-5. 

Preclinical Drag Disposition A Laboratory Handbook, Francis L S. Tse and James... 

The hepatic disposition parameters of a drag, representing reversible and irreversible processes, are calculated using the following equations ... 

The same statistical analytical method used for the liver can be applied to examine the disposition characteristics of a drag in the kidney. The following parameters are important to understand the renal disposition of drag ... 

Evans WE, McLeod HL. Pharmacogenomics—drug disposition, drag targets, and side effects. N Engl J Med 2003 348 538-549. 

Intraocular disposition of microencapsulated and nanoencapsulated antivirals have been of interest to several groups. Except for transient interference with vision, they seem to be attractive as drag delivery systems, especially because of their binding abilities to certain intraocular tissues. 

A pharmacokinetic (PK) study in individuals with impaired renal function is recommended when renal impairment is likely significantly to alter the disposition of a drug/or its active metabolite(s) such that a dose adjustment may be needed. In the main, this is the case primarily for drags that are mainly eliminated (excretion and/or metabolism) by the kidneys and/or if a drug has a narrow therapeutic window. However, severe re-... 

Some paradoxes of the turbulence in canopies, or EPRs, were pointed out by Raupach and Thom in their state-of-art review of 1981, [522], The first phenomenon is the value of the drag coefficient of elements that constitute the EPR. The highly precise measurements in aerodynamic tubes brought values that depend on the obstacle shape, the flow turbulence level, and the mutual disposition of obstacles but vary near cf 0.5 for spheres and cf 1 for cylinders in the working range of the local Reynolds number 103 < Re < 105. The same coefficient determined from the field measurements in forests turned out to be several times less (in this case, the indirect calculations were performed). A similar paradox takes place for the exchange coefficients. 

Custodio JM, Wu C-Y, Benet LZ. Predicting drug disposition, absorption/elimination/ transporter interplay and the role of food on drag absorption. Adv Drag Del Reviews 2008 60 717-733. 

Sakagami M. In vivo, in vitro and ex vivo models to assess pulmonary absorption and disposition of inhaled therapeutics for systemic delivery. Adv Drag Deliv Rev 2006 58 1030-1060. 

I Pharmacokinetics is concerned with the time-course and disposition of drags in the... 

Wang, B., You, G., 8c Morris, M. (2007). Drag Transporters Molecular Characterization and Role in Drug Disposition. Hoboken Wiley-Interscience. 

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