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Dr. Reddy’s Laboratories

An example is the AstraZenecas anticholesterol drug Crestor (rosuvastatin). Although the patent expires only in 2012, there are already about 25 manufacturers in India, including famous names such as Ranbaxy (Rosuvas) and Dr Reddy s Laboratories (Rosvat). [Pg.135]

Several patents have recently published that claim the preparation of several different hydrates and polymorphic crystal forms of olanzapine. Dr. Reddy s Laboratories has recently disclosed the preparation of the monohydrate and the dihydrate of olanzapine. A mixture of 24 and A-methylpiperazine was refluxed in DMSO and toluene and then cooled (Scheme 8). Water was added and the precipitate was filtered and washed with water. The resulting solid was placed under vacuum at 30 to 50 °C to give the monohydrate or at ambient temperature to give the dihydrate. Recrystallization of crude olanzapine or one of its hydrates from CH2CI2 provided crystal form 1, whereas recrystallization from EtOAc provides crystal form 2. [Pg.98]

So, a catalyhc synthesis of solefinacin (2) was developed at Dr. Reddy s Laboratories [28]. Mechanishc analysis reveals that the use of stoichiometric NaH is not required, as ethoxide anions are liberated. This anion is basic enough to deprotonate the (R)-quinuclidin-3-ol (31) and is capable of driving the reachon to completion, as shown in Scheme 14.8. The entire process is thus catalytic with respect to NaH ... [Pg.299]

We thank Dr. Reddy s Laboratories for supporting this work. [Pg.308]

A Diels-Alder approach to varenicline was recently published by Dr. Reddy s Laboratories. Entry to a key bicyclic intermediate is achieved by an iodide-catalyzed Diels-Alder reaction of tetrabromo dimethyl pyrazine (47) with excess norbomadiene. Dihydroxylation of 48, oxidative cleavage, and reductive amination prepares N-p-methoxybenzyl varenicline (50), which is deprotected under transfer hydrogenation conditions to give varenicline (1) in 10% yield for the sequence.47 This approach continues the theme of building the piperidine of 1 through olefin oxidative cleavage and reductive amination, but by doing so late in the sequence however, the approach... [Pg.243]

Dr. Reddy s Laboratories has also disclosed a synthetic route to aprepitant, which uses an oxidation/reduction sequence as the key step to afford the desired cis-... [Pg.286]

For instance. Dr. Reddy s Laboratories, Nicholas Piramal Ltd., Divi s Laboratories and Natco Pharma, all based in Hyderabad, Andhra Pradesh, India have modem technologies for production of dilitiazem, and they are collectively capable of producing 1000 tpa of dilitiazem. However, actual production has been much less. The scenario may change if one or two global majors decide to close down their production and decide to source the material from India. [Pg.143]

In addition to the structures already discussed, Dr Reddy s Laboratories in collaboration with Perlecan Pharma are developing DRF10945, an oral PPARa agonist, for the potential treatment of dyslipidemia, which is currently in clinical phase 2. [Pg.421]

Prof. Javed Iqbal, PhD, fna Distinguished Research Scientist Head Discovery Research Dr. Reddy s Laboratories Ltd. Miyapur, Hyderabad - 500 050, India... [Pg.268]

Carvedilol was supplied by Dr. Reddy s Laboratory, Hyderabad, India as a gift sample. Poloxamer F68 and F127 were supplied by Lupin Research Park, Pune, India. All other chemicals used were of analytical grade. [Pg.636]

Other chiral phosphine-phosphites with relevance to application in AHF are those derived from BIPHEN (Scheme 2.141), as claimed by ChiroTech Technology Ltd./Dr Reddy s Laboratories [35]. Their total synthesis starts with enantiopure l-hydroxy-2,5-diphenylphospholane 1-oxide, which is available via a multistep approach suggested by Fiaud et al. [36]. This material is converted via its borane adduct into the corresponding hydroxymethyl compound by addition to paraformaldehyde. Phosphorylation of the alcohol with enantiopure BIPHEN-X (X = C1, Br, or I) produces the phosphite. The use of phosphorbromidite or the relevant iodide sometimes avoids the need for higher temperatures, which... [Pg.215]

Dr Reddy s Laboratories claimed the diastereoselective hydroformylation of an enantiopure bicyclic lactam by means of a Rh[(/ ,/ )-Kelliphite] catalyst (Scheme 4.59) [18]. The olefinic substrate that is produced on a multi-ton scale by Chirotech gives after hydroformylation and a single crystallization step the almost pure aldehyde. Noteworthy, (S,S)-Kelliphite or other ligands, such as (/J,/ ,S)-Bisdiazaphos or (achiral) BIPHEPHOS, induced mainly the formation of the undesired regioisomeric aldehyde. The reaction has been upscaled to 15 g of substrate and used eventually for the production of multifunctionalized... [Pg.332]

Dr Reddy s Laboratories has reported more detailed studies on the synthesis of pharmaceutical intermediates using direct amidation technology... [Pg.213]

D.E. Verral, Method for making polyethylene glycol carbonates, U. S. Patent 7816484, assigned to Dr. Reddy s Laboratories Inc., October 19,2010. [Pg.85]

The particular reactivity of free alcohols in Ru-catalyzed alkene metathesis is imder-scored by the observation Tetrahedron Lett. 2007, 48,6905) by laved Iqbal of Dr. Reddy s Laboratories, Ltd., Miyapur that attempted metathesis of the ether 4a faded, but metathesis of the diol 4b proceeded efficiently. Kazunori Koide of the University of Pittsburgh has demonstrated (Organic Lett. 2007, 9, 5235) that the yields of cross-metathesis with an alkenyl alcohol could be enhanced by binding it to a trityl resin. He observed that the Grela catalyst 8 was particularly effective in this application. [Pg.46]

AsN. Selvakumar of Dr. Reddy s Laboratories, Ltd., Hyderabad approached (reira/iedron Lett. 2007,48, 2021) the synthesis of phaseolinic acid 6, there was some concern about the projected cyclization of 2 to 3, as this would involve the coupling of two electron-deficient alkenes. In fact, the Ru-mediated ring-closing metathesis proceeded efficiently. The product unsaturated lactone 3 could be reduced selectively to either the trans product 4 or the cis product 5. [Pg.54]

Another example of Negishi coupling using Pd(OAc)2 on commercial scale was explored by Praveen et al. [37] from Dr. Reddy s Laboratories for the synthesis of an acyl-CoA cholesterol acyltransferase inhibitor, ezetimibe 102. The carboxylic acid 98 was converted into acid chloride 99 and directly incorporated in a large-scale Negishi coupling with arylzinc complex 100 in the presence of Pd(OAc)2 catalyst to afford the aryl ketone 101 (Scheme 9.25). [Pg.346]


See other pages where Dr. Reddy’s Laboratories is mentioned: [Pg.297]    [Pg.388]    [Pg.209]    [Pg.288]    [Pg.405]    [Pg.841]    [Pg.911]    [Pg.1429]    [Pg.1612]    [Pg.1636]    [Pg.2014]    [Pg.2066]    [Pg.2509]    [Pg.2543]    [Pg.3055]    [Pg.214]    [Pg.718]    [Pg.76]    [Pg.701]    [Pg.269]    [Pg.645]    [Pg.230]    [Pg.231]    [Pg.360]    [Pg.164]    [Pg.214]    [Pg.93]   
See also in sourсe #XX -- [ Pg.244 , Pg.286 ]

See also in sourсe #XX -- [ Pg.214 ]




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