Chirotech Technology

Dowpharma, Chirotech Technology Limited, 162 Cambridge Science Park, Milton... 

Chirotech Technology Limited The Dow Chemical Company 321 Cambridge Science Park Milton Road Cambridge CB4 0WG UK... 

M.J. Burk, F. Bienewald, A. Zanotti-Gerosa (Chirotech Technology Limited), WO 99/52852. 

Dowpharma, Chirotech Technology Ltd, A Subsidiary of The Dow Chemical Company,... 

A common application of aryl halides is Pd-mediated coupling to form C-C bonds. Graham Meek of Chirotech Technology Ltd., Cambridge, UK has found (Tetrahedron Lett. 2004,45, 9277) that the enamide 6 participates efficiently in Heck coupling. The product 7 is an excellent substrate for enantioselective hydrogenation, to give 8. 

Chirotech Technology Limited, Chiroscience pic, Cambridge, England... 

Mark J. Burk, Ph.D. Head, ChiroTech Technology Limited, Chiroscience PIC., Cambridge, United Kingdom... 

Figure 6.9. An example of a chiral separation using a macrocyclic chirobiotic column of unnatural amino acids as chiral synthesis intermediates. Courtesy of Chirotech Technologies, UK.

Raymond McCague Chirotech Technology Ltd., Cambridge, United Kingdom Robert J. McNair Johnson Matthey, West Deptford, New Jersey, U.S.A. 

More recently, the discovery and commercialization of L-aminoacylase from Thermococcus litorali was a product of the LINK project between Chirotech Technology and the University of Exeter. The L-aminoacylase of T. litoralis had broad substrate specificity for the hydrolysis of N-acylated a-amino acids, with respect to both the side chain and the N-acyl group. It is especially useful for the enantiospecific hydrolysis of acyl groups, particularly N-benzoyl groups of a-amino acids. This can be used to advantage in synthetic processes that require the enantiospecific deprotection of racemates [29]. 

The Separation of the Enantiomers of 2 -Bromophenylalanine and 3-Bromophenylalanine Courtesy of Chirotech Technology Ltd. 

Fluprostenol was marketed in form of its racemate by ICI as a contraceptive in the veterinary sector. The synthetic route developed for this product proceeds via the Corey lactone, whereby the side-chains are built up using Horner-Wadsworth-Emmons or Wittig reactions. Travoprost, the enantio-merically pure isopropyl ester of fluprostenol, is a potent anti-glaucoma drug, for which Chirotech Technology Ltd. has published an interesting synthesis (Fig. 5.102). [229]... 

Chirotech Technology Ltd, Dr. Reddy s Custom PharmaceuUcal Services, Cambridge CB4 OPE, UK... 

Other chiral phosphine-phosphites with relevance to application in AHF are those derived from BIPHEN (Scheme 2.141), as claimed by ChiroTech Technology Ltd./Dr Reddy s Laboratories [35]. Their total synthesis starts with enantiopure l-hydroxy-2,5-diphenylphospholane 1-oxide, which is available via a multistep approach suggested by Fiaud et al. [36]. This material is converted via its borane adduct into the corresponding hydroxymethyl compound by addition to paraformaldehyde. Phosphorylation of the alcohol with enantiopure BIPHEN-X (X = C1, Br, or I) produces the phosphite. The use of phosphorbromidite or the relevant iodide sometimes avoids the need for higher temperatures, which... 

Scheme 4.47 Chirotech technology s hydroformylation access to peptidic drugs.

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