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Hepatitis doxycycline

Rifampin is known to induce the hepatic microsomal enzymes that metabolize various drugs such as acetaminophen, oral anticoagulants, barbiturates, benzodiazepines, beta blockers, chloramphenicol, clofibrate, oral contraceptives, corticosteroids, cyclosporine, disopyramide, estrogens, hydantoins, mexiletine, quinidine, sulfones, sulfonylureas, theophyllines, tocainide, verapamil, digoxin, enalapril, morphine, nifedipine, ondansetron, progestins, protease inhibitors, buspirone, delavirdine, doxycycline, fluoroquinolones, losartan, macrolides, sulfonylureas, tacrolimus, thyroid hormones, TCAs, zolpidem, zidovudine, and ketoconazole. The therapeutic effects of these drugs may be decreased. [Pg.1717]

HA, mild pain Action Nonnarco tic analgesic w/ barbiturate Dose 1—2 tabs or caps PO q4-6h PRN i in renal/hepatic impair 4 g/24 h APAP max Caution [C, D, +] Alcoholic liver Dz Contra G6PD deficiency Disp Caps, Liq, tabs SE Drowsiness, dizziness, hangover effect Interactions T Effects OF benzodiazepines, opiate analgesics, sedatives/hypnotics, EtOH, methylphenidate hydrochloride i effects OF MAOIs, TCAs, corticosteroids, theophylline, OCPs, BBs, doxycycline EMS See Acetaminophen may impair coordination, monitor for depression concurrent EtOH use T CNS depression butalbital is habit forming... [Pg.61]

DOXYCYCLINE ANTIEPILEPTICS -BARBITURATES, CARBAMAZEPINE, PHENYTOIN i doxycydine levels, with risk of therapeutic failure Induction of hepatic metabolism Monitor for i clinical efficacy and t dose as required... [Pg.547]

Patient C. A 49-year-old woman reported by her family to have hepatitis C was evacuated from New Orleans after a boat rescue. She visited an Arkansas hospital on September 4 with bullae, septic shock, and necrotizing fasciitis on her left leg, which was extensively debrided. V. vulnificus was isolated from her blood. As of September 12, she was being treated with ceftazidime and doxycycline and remained in critical condition. [Pg.361]

Preventing the initial hepatic cycle. This is also called causal prophylaxis. Primaquine has long been regarded as too toxic for prolonged use but evidence now suggests it may be used safely, and it is inexpensive proguanil is weakly effective. Doxycycline may be used short-term. [Pg.269]

In isolated cases, pronounced Lyme hepatitis develops. The pathogen is often identifiable in liver cells and sinusoids. Treatment consists of doxycycline or erythromycin. [Pg.480]

Minocycline and doxycycline are predominantly eliminated by the liver and biliary tract (70-90%). Therefore, no change in dose is needed in patients with impaired renal function. However, it should be considered that hepatic elimination of doxycychne or minocycline might be accelerated by co-administration of agents that induce hepatic enzymes. [Pg.1190]

The tetracyclines, apart from doxycycline and minocycline, are slowly eliminated by renal excretion (glomerular filtration). Their slow elimination can be attributed to enterohepatic circulation whereby drug excreted by the liver in bile is reabsorbed from the intestine. The half-life of oxytetracycline differs widely between animal species goat (3.4 h), cattle (4.0 h), sheep (5.2 h), dog (6.0 h), pig (6.0 h), donkey (6.5 h), horse (9.6 h), and red-necked wallaby (.Macropus rufogriseus) (11.4 h). Doxycycline, unlike other tetracyclines, is eliminated by biliary excretion and diffusion into the intestine. The half-life of doxycycline is relatively short in dogs (7.0 h) and cats (4.6 h) compared with human beings (16 h). The half-life of doxycycline in chickens (4.8 h) is shorter than in turkeys (10 h) (Santos et al, 1996). Minocycline is mainly eliminated by hepatic metabolism. [Pg.34]

Doxycycline at recommended doses does not accumulate significantly in patients with renal failure and thus is one of the safest of the tetracyclines for use in patients with renal impairment. The drug is excreted in the feces. Its half-life may be significantly shortened by concurrent therapy with barbiturates, phenytoin, rifampin, or other inducers of hepatic microsomal enzymes. [Pg.190]

B. Pharmacokinetics Oral absorption is variable, especially for the older drugs, and may be impaired by foods and multivalent cations (calcium, iron, aluminum). Tetracyclines have a wide tissue distribution and cross the placental barrier. All of the tetracyclines undergo entero-hepatic cycling. Doxycycline is excreted mainly in feces the other drugs are eliminated primarily in the urine. The half-lives of doxycycline and minocycline are longer than those of other tetracyclines. [Pg.387]

Antimicrobial drugs that are eliminated via hepatic metabolism or biliary excretion include erythromycin, cefoperazone, clindamycin, doxycycline, isoniazid, ketoconazole, and nafcillin. The answer is (C). [Pg.454]

Liver Hepatitis has been attributed to doxycycline in a 37-year-old man with a strong family history of autoimmune diseases [120 ]. [Pg.499]

Chavant F, Lafay-Chebassier C, Beauchant M, Perault-Pochat MC. Hepatite a la doxycycline. [Doxycycline induced hepatitis.] Gastroenterol Clin Biol 2008 32 (10) 825-7. [Pg.506]


See other pages where Hepatitis doxycycline is mentioned: [Pg.144]    [Pg.294]    [Pg.61]    [Pg.141]    [Pg.255]    [Pg.274]    [Pg.56]    [Pg.1006]    [Pg.1121]    [Pg.253]    [Pg.255]    [Pg.274]    [Pg.1059]    [Pg.280]    [Pg.191]    [Pg.420]    [Pg.478]    [Pg.481]    [Pg.481]    [Pg.223]    [Pg.259]    [Pg.491]    [Pg.495]    [Pg.1763]    [Pg.190]    [Pg.420]    [Pg.445]    [Pg.144]    [Pg.141]    [Pg.255]    [Pg.274]   
See also in sourсe #XX -- [ Pg.499 ]




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Doxycyclin

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