Domains context

The preceding considerations impose serious limitations on simple pairwise alignments that can be overcome in multiple alignments. With sufficient members of a multialignment, both the domain structure and the functionally conserved pattern within that domain context can be discerned. This is true even when the fold of the domain context is indeterminate. 

Analyzing the fusion of genes borders on the analysis of proteins in terms of the domain composition. For examples of the variation of domain context, see the chapter by Ponting et al. in this volume. 

Or, maybe, that z = x + iy is the standard symbol for a complex variable in a domain context, and the convention goes a lot further back. 

Heilshom SC, Liu JC, Tirrell DA (2005) Cell-binding domain context affects cell behavior on engineered proteins. Biomacromolecules 6 318-323... 

Descriptions given in Section 4 of this chapter about the imposition of boundary conditions are mainly in the context of finite element models that use elements. In models that use Hermite elements derivatives of field variable should also be included in the set of required boundai conditions. In these problems it is necessary to ensure tluit appropriate normality and tangen-tiality conditions along the boundaries of the domain are satisfied (Petera and Pittman, 1994). 

Today, the use of CHIRBASE as a tool in aiding the chemist in the identification of appropriate CSPs has produced impressive and valuable results. Although recent developments diminish the need for domain expertise, today the user must possess a certain level of knowledge of analytical chemistry and chiral chromatography. Nevertheless, further refinements will notably reduce this required level of expertise. Part of this effort will include the design of an expert system which will provide rule sets for each CSP in a given sample search context. The expert system will also be able to query the user about the specific requisites for each sample (scale, solubility, etc.) and generate rules which will indicate a ranked list of CSPs as well their most suitable experimental conditions (mobile phase, temperature, pH, etc.). 

The human PR exists as two functionally distinct isoforms PRA and PRB transcribed from two promoters from a single gene. PRA lacks the N-terminal 164 aa and is a 769 aa protein. PRB functions as a transcriptional activator in most cell and promoter contexts. In contrast, PRA is transcriptionally inactive and functions as a strong ligand-dependent transdominant repressor of SHR transcriptional activity. Different cofactor interactions were demonstrated for PRA and PRB, probably due to an inhibitory domain within the first 140 aa of PRA, which is masked in PRB. Both PR isoforms however, repress estradiol-induced ER activity when liganded. Several other mRNA isoforms are present in PR-positive tissues such as breast cancer with unknown clinical significance. 

There are a number of industrial and technological areas in which nanoscale adhesion is important. One of the earliest fields concerned with adhesion on this scale was colloid science. Colloid particles lie in the intermediate region between macro and nano, with dimensions typically of the order of hundreds of nanometers up to a few microns. This means that their true contact areas he well within the nano-domain and are influenced by interactions on this length scale. Adhesion between such particles is important, due to its influence on mineral separation processes and on the aggregation of powders, for example, on the walls of machinery or in the forming of medical tablets. In an extraterrestrial context, such... 

The tools for in silico toxicology are broadly applied in the drug development process. The particular use of the tools is clearly context-dependent, which includes the quality of the prediction and the applicability domain of the model. 

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