Dogger Bank itch

Contact with the bryozoan Alcyonidium gelatinosum gives rise to Dogger Bank itch , an allergic contact dermatitis. The causative agent is (2-hydroxyethyl)dimethylsulfoxonium ion (1). Synthesis of 1 was achieved by base-catalysed condensation of trimethylsulfoxonium chloride and formaldehyde [26]. 

Hydroxyethyl)dimethylsuIfoxonium chloride (1), the causative agent of Dogger Bank Itch which has previously been isolated from the marine bryozoan Alcyonidium gelatinosum [26], has now been isolated as a cytotoxic component of the marine sponge Theonella aff. mirabilis [506],... 

Bonnevie P (1948) Fishermen s Dogger Bank Itch allergic contact eczema due to coralline Alcyonidium hirsutumy Sie sea-chervil. Acta Allergol 1 40-46 Burnett JW (1962) Uncommon bacterial infections of the skin. Arch Dermatol 86 597-607... 

Dogger Bank Itch. 2. An Allergic Contact Dermatitis. Bull. Soc. Chim. Belg. 89,1087 (1980). 

Dogger Bank Itch. 4. An Eczema-Causing Sulfoxonium Ion from the Marine Animal, Alcyonidium gelatinosum (Bryozoa). Toxicon 20, 307 (1982). 

The polychaetes are almost exclusively marine, and the number of species is estimated at 10000. There has been much work on their primary and secondary metabolites. The numerous bristles serve as a means of locomotion, and for species of the family Amphinomidae, as defense organs that can inject venom at the slightest touch. Thus, the bristleworm Eurythoe complanata (marine fire-worm ), foimd in all tropical waters, secretes the quaternary ammonium salt complanine, which may produce the skin inflammation that occurs on physical contact with the worm (Nakamura et al, 2008). This inflammatory mechanism appears similar to that of Dogger Bank itch which is provoked by a sulfoxonium salt produced by a bryozoan (see Chapter 22). Later on, two new related compotmds, neocomplanines A and B were isolated from the same organism (Nakamura et al, 2010). 

Bonnevie, P. (1948) Fishermen s Dogger Bank itch . Acta Allergol., 1, 40-46. 

Carle, J.S. and Christophersen, C. (1980b) Dogger Bank itch the allergen is (2-hydroxyelhyl)-dimethylsulfoxonium ion. J. Am. Chem. Soc., 102, 5107-5108. 

Pathmanaban, O.N., Porter, J.-S., and White, l.R. (2005) Dogger Bank itch in the eastern English channel a newly described geographical distribution of an old problem. Clin. Exp. Dermatol., 30, 622-626. 

Warabi, K., Nakao, Y., Matsunaga, S., Fukuyama, T, Kan, T, Yokoshima, S., and Fusetani, N. (2001) Dogger Bank itch revisited isolation of (2-hydroxyethyl)dimethylsuIfoxonium chloride as a cytotoxic constituent from the marine sponge TheoneUa aff. mirabilis. Comp, Biochem, Physiol, 128B, 27-30. 

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