Does Enhanced Sensitivity Improve Methods

We wish to optimize the detecting components of an established HPLC method. Which parameter will provide a reliable characterization of the improvements achieved  

The example will give us the opportunity to introduce reliable characteristic data as well as some criteria for visually evaluating the calibration function and the respective, specially designed residuals plot [1, 2]. We will be able to recognize an efficient improvement at one glimpse. 

The measurements of the calibration series to be considered are given in Table 1. The response of method 2 clearly seems to be the better one. The detector used was based on additional electronic amplification of input signals. 

Sensitivity is given by the slope of the calibration function applied for the desired operating point. Because we are also going to consider nonlinear calibrations, with their sensitivity being dependent on the operating point, we focus on the middle of the working range. This will enable sensitivity data to be compared numerically and visually for any calibration function that may apply. 

The characteristics and especially the ranges of uncertainty that prove approximately equal for the concentration evaluated, are given numerically as well as 

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Does enhanced sensitivity mean improved methods. ... 

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