DO mice

MOUSE POPULATION-BASED TOXICOLOGY FOR PERSONALIZED MEDICINE AND IMPROVED SAFETY PREDICTION 

The utility of using DO mice to model human disease and population-level responses has been demonstrated in recent manuscripts. As with CC mice, DO mice have been employed as a tool to study a variety of human conditions, including pain sensitivity (Recla et al., 2014), development of atherosclerosis (Smallwood et al., 2014), susceptibility to Mycobacterium tuberculosis infection (Harrison et al., 2014), and neurobehavioral traits (Logan et al., 2013), including addiction to drugs of abuse (Dickson et al., 2015). 

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Mice and voles store similar molybdenum amounts in the DM of their body (Table 18.3), but shrews - which are insecti-vores - accumulate significantly more molybdenum than do mice and voles. Insects may also be rich in molybdenum (Anke et al. 2003). 

Smith J, Lloyd R, Atherton D, et al. 1976. The early retention and distribution of monomeric 237Pu(IV) and 239Pu(IV) in C57BL/Do mice. In Webster S, ed. The health effects of plutonium and radium. Salt Lake City, LIT J.W. Press, 7-20. 

DO Because DO mice are maintained by a mouse distributor, there are strict exclusion criteria for animal housing. Exclusion criteria and reporting requirements can be found by accessing http //jaxmice.jax.org/ health/agents list.html. Production facility reports for DO mice include monitoring data for common mouse pathogens. Current health reports may be accessed at http //jaxmice.jax. org/strain/009376.html under the Technical Support drop down menu. 

Gatti, D.M., Broman, K., Shahalin, A., 2014a. DOQTL Genotyping and QTL Mapping in DO Mice. Bioconductor. 

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