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DNA bend

Steitz has suggested that DNA bending by CAP could contribute to activation of transcription by looping the DNA around CAP to provide for contacts between RNA polymerase and DNA upstream of the CAP-binding site. Such a model could explain how CAP can activate transcription from a variety of distances from the RNA polymerase-binding site since the size of the loop could vary. [Pg.147]

The sharp bend of DNA at the TATA box induced by TBP binding is favorable for the formation of the complete DNA control module in particular, for the interaction of specific transcription factors with TFIID. Since these factors may bind to DNA several hundred base pairs away from the TATA box, and at the same time may interact with TBP through one or several TAFs, there must be several protein-DNA interactions within this module that distort the regular B-DNA structure (see Figure 9.2). The DNA bend caused by the binding of TBP to the TATA box is one important step to bring activators near to the site of action of RNA polymerase. [Pg.158]

Lac repressor binds to both the major and minor grooves inducing a sharp bend in the DNA CAP-induced DNA bending could activate transcription Conclusion Selected readings... [Pg.415]

Recognition of DNA sequence and DNA bending and molecular design for artificial repressors 97YGK384. [Pg.263]

Regulation of mRNA transcription and DNA bending by using triple helix forming oligonucleotide 99YGK194. [Pg.263]

Akhmedov AT, Gross B, Jessberger R 1999 Mammalian SMC3 C-terminal and coiled-coil protein domains specifically bind palindromic DNA, do not block DNA ends, and prevent DNA bending. J Biol Chem 274 38216-38224... [Pg.129]

The interstrand cross-link also induces DNA bending.72 X-ray and NMR studies on this adduct show that platinum is located in the minor groove and the cytosines of the d(GC) base pair involved in interstrand cross-link formation are flipped out of the helix stack and a localized Z-form DNA is observed.83-85 This is a highly unusual structure and very distorting—implications for differential repair of the two adducts have been addressed. Alternatively, the interstrand cross-link of the antitumor inactive trans-DDP is formed between a guanine (G) and its complementary cytosine (C) on the same base p a i r.86,87/ nms- D D P is sterically incapable of producing 1,2-intrastrand adducts and this feature has been cited as a dominant structural reason for its lack of antitumor efficacy. It is clear that the structural distortions induced on the DNA are very different and likely to induce distinctly different biological consequences. [Pg.816]

Lia G, Praly E, Ferreira H, Stockdale C, Tse-Dinh YC, Dunlap D, Croquette V, Bensimon D, Owen-Hughes T (2006) Direct observation of DNA distortion by the RSC complex. Mol Cell 21 417 25 Lorch Y, Davis B, Kornberg RD (2005) Chromatin remodeling by DNA bending, not twisting. Proc Natl Acad Sci U S A 102 1329-1332 Luger K (2006) Dynamic nucleosomes. Chromosome Res 14 5-16... [Pg.42]

Nucleolin together with HnRNP D has been shown to form the LRl transcription factor. LRl is a B cell-specific, sequence-specific DNA binding activity that regulates transcription in activated B cells (Hanakahi et at, 1997 Hanakahi and Maizels, 2000). DNA bending induced by nucleolin and hnRNP D might regulate the transcriptional activation by LRl (Hanakahi and Maizels, 2000). [Pg.129]

IHF DNA bending Global regulator IHFa 4 17 H2 dependent Non-essential activator... [Pg.64]

B. Audit, C. Vaillant, A. Arneodo, Y. d Aubenton-Carafa, and C. Thermes, Long-range correlations between DNA bending sites Relation to the structure and dynamics of nucleo-somes. J. Mol. Biol. 316, 903-918 (2002). [Pg.245]

Lorenz, M., Hillisch, A., Payet, D., Buttinelli, M., Travers, A., and Diekmann, S. (1999) DNA bending induced by high mobility group proteins studied by fluorescence resonance energy transfer. Biochemistry 38, 12150-12158. [Pg.126]

Lnenicek-Allen, M., Read, C.M., and Crane-Robinson, C. (1996) The DNA bend angle and binding affinity of an HMG box is increased by the presence of short terminal arms. Nucleic Acids Res. 24, 1047-1051. [Pg.127]


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