DNA-adamantane-amino acid nanostructures

Bifunctional adamantyl, as a hydrophobic central core, can be used to construct peptidic scaffolding [151], as shown in Fig. 27. This is the reason why adamantane is considered one of the best MBBs. This may be considered an effective and practical strategy to substitute different amino acids or DNA segments on the adamantane core (Fig. 28). In other words, one may exploit nucleic acid (DNA or RNA) sequences as linkers and DNA hybridization (DNA probe) to attach to these modules with an adamantane core. Thus a DNA-adamantane-amino acid nanostructure may be produced. 

DNA-Directed Assembly and DNA-Adamantane-Amino acid Nanostructures... 

Adamantane can be used to construct peptidic scaffolding and in synthesis of artificial proteins. Adamantane has also been introduced into different types of synthetic peptidic macrocycles, which are useful nanotools for many applications including in peptide- and stereochemistry. Introduction of amino-acid-functionalized adamantane to the DNA nanosttuctures may lead to constraction of DNA-adamantane-amino acid nanostructures with desirable stiflhess and integrity. Diamondoids can be employed to construct molecular rods, nanocages, nanocapsules, and also for utilization in different methods of self-assembly. In fact, by development of self-assembly approaches and utilization of diamondoids in these processes, it should be possible to construct novel nanostructures especially to design effective and specific in vivo carriers for drugs. 

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