Dizziness minocycline

Adverse effects with the tetracyclines include gastrointestinal upset drug interactions with dairy products, antacids, and iron and phototoxicity. Minocycline can also cause vestibular complications (headache and dizziness) and skin discoloration that is not typical with tetracycline and doxycycline.16... 

Minocycline (Solodyn) [Antibiotic/Tetracycline] Uses Acne Action Tetracycline, bactmostatic Dose Adults Peds >12 y. 1 mg/kg PO daily X 12wk w/ food to -1- irritation Caution [C, ] assoc w/ pseudomembranous colitis w/ renal impair Contra AU gy, women of childbearing potential Disp Tabs SE D, HA, fevCT, rash, joint pain, fatigue, dizziness Interactions t Effects OF digoxin, oral anticoagulants t risk of n hrotox W/ methoxyflurane X effects W/... 

Vestibular reactions like dizziness, vertigo, nausea and vomiting are particular for minocycline. Especially in pregnant women and when given in high doses hepatotoxicity has been described. Also patients with preexisting liver disease are susceptible. In patients with kidney disease renal function can further deteriorate. 

Dizziness, vertigo, nausea, and vomiting have been noted particularly with doxycycline at doses above 100 mg. With dosages of 200-400 mg/d of minocycline, 35-70% of patients will have these reactions. 

Vestibular problems These side effects (for example, dizziness, nausea, vomiting) occur with minocycline, which concentrates in the endolymph of the ear and affects function. 

Vestibular toxicity appears to be unique to minocycline. Lightheadedness, loss of balance, dizziness, nausea, and tinnitus beginning 2 to 3 days after starting therapy can occur in up to 70% of patients. Although these side effects are usually reversible after discontinuing the drug, they have severely limited the use of minocycline. 

Minocycline differs from other tetracyclines in that its antibacterial spectrum includes Neisseria meningitidis and it has been used for meningococcal prophylaxis. It is well absorbed from the gut, even after a meal, partly metabolised in the liver and partly excreted in the bile and urine (t/ 15 h). Dose reduction is not necessary when renal function is impaired 200 mg initially is followed by 100 mg 12-hourly. Minocycline but not other tetracyclines may cause a reversible vestibular disturbance with dizziness, tinnitus and impaired balance, especially in women. 

Minocycline has better gastrointestinal absorption than tetracycline and may be less photosensitizing than either tetracycline or doxycycline. Side effects of minocycline include dizziness and hyperpigmentation of the skin and mucosa, serum-sickness-like reactions, and drug-induced lupus erythematosus. With all the tetracyclines, vaginal candidiasis is a common complication that is readily treated with local administration of antifungal drugs. 

The systentic administration of demeclocycline elicits photosensitization to ultraviolet light or sunlight. Minocycline causes vertigo and dizziness. The intravenous adntinistration of tetracyclines has been observed to cause venous thrombosis. 

Vestibular toxicity Dose-dependent reversible dizziness and vertigo have been reported with doxycycUne and minocycline. 

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