Divinyl resins, synthesis using

Polystyrene resin, frequently used resin material for solid-phase peptide synthesis (SPPS). The polymeric support for SPPS must be chemically inert, mechanically stable, completely insoluble in the solvents used, and easily separated by filtration. For many applications a copolymer of polystyrene with 1% of divinyl benzene as crosslinker is used. The dry resin beads are able to swell up to the five-or sixfold volume in the different organic solvents mainly used for peptide synthesis (e.g., dichloromethane or dimethylfor-mamide). For SPPS the resin material must be chemically functionalized in order to allow for attachment of a handle/liker (e.g. Wang resin), or the first amino acid (—> Merrifield resin). Hydrophilic tentacle polymers gels (TentaGel) are obtained by grafting polyethylene glycol (PEG) chains with an arbitrary degree of polymerization onto porous polystyrene beads. 

Scheme 6. Synthesis of Divinyl Resins Using Diisocyanate Linkers O...

Styrene-divinyl benzene resins have been used as typical support for the metal containing catalysts bound to them. The synthesis of these polymeric reagents has involved several approaches depending on the application which they are intended. The immobilization of transition metals on polymer supports involves using polymers containing ligands which can complex with the metal such that the coordination sphere of the metal remains essentially the same as in... 

The field of organic chemistry has seen the most extensive use of polymeric materials as aids in effecting chemical transformation and product isolation. Insoluble polymer supports have been used as handles to facilitate these functions. As chemical reagents can be bound to an insoluble polymer carrier and used in organic synthesis [117,118], polymer-bound reagents can also be used to assist in the purification step of solution-phase reactions [119,120]. The latter are known as scavenger resins. These are added to the reaction mixture upon completion of the reaction in order to quench and selectively bind to the unreacted reagents or by-products. The polymer-bound impurities are then removed firom the product by simple filtration to obtain pure compounds. For example, aminomethylated poly(styrene-co-divinyl benzene) can be used to remove acid chlorides, sulfonyl chlorides, isocyanates, thiocyanates, and proton. Similarly, 2-Chlorotrityl resins have been developed for the attachment of carboxylic acids, alcohols. 

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