Divinyl ether-maleic acid copolymers

Polymers other than polynucleotides also have been found to induce interferon. Pyran-2-succinic anhydride, 4,5-dicar-boxy tetrahydro- 6-methyl- anhydride polymers in low daily doses protect mice infected with lethal doses of Friend or Rauscher leukemia virus. A correlation between degree of protection and interferon levels was noted. Vinyl sulfate polymers and divinyl ether-maleic acid copolymers induce interferon and protect mice against lethal virus infections. Both of these substances had activity that could not be accounted for by interferon alone. The dependency on molecular weight of polyacrylic acid polymers for interferon induction indicated a... 

H. Maeda, T. Sawa, and T. Konno, Mechanism of tumor-targeted dehvery of macromolec-ular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS, /. Control. Release, 74 (1-3), 47-61,2001 H. Yamamoto, T. Miki, T. Oda, T. Hirano, Y. Sera, M. Akagi, and H. Maeda, Reduced bone marrow toxicity of neocarzinostatin by conjugation with divinyl ether-maleic acid copolymer, Eur. J. Cancer, 26 (3), 253-260,1990. 

Kaneda Y, Yamamoto Y, Kamada H, Tsunoda S, Tsutsumi Y, Hirano T, Mayumi Y (1998) Antitumor activity of tumor necrosis factor alpha conjugated with divinyl ether and maleic acid anhydride copolymer on solid tumors in mice. Cancer Res 58 290-295... 

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