Diversity-Oriented Fluorescent Libraries

SOLID-PHASE SYNTHESIS OF DYES AND THEIR APPLICATION AS SENSORS AND BIOIMAGING PROBES 

Environmentally-sensitive fluorescent structures are interesting scaffolds for probe development. On account of the high sensitivity of the dapoxyl core (2-pyridyl-5-aryl- 

Although the rapid synthesis, broad chemical diversity, and adaptability to high-throughput screenings of solid-phase approaches had clearly benefited the development 

Houghten, C. Pinilla, S. E. Blondelle, J. R. Appel, C. T. Dooley, J. H. Cuervo, Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery. Nature 1991, 354, 84-86. 

Salmon, E. M. Hersh, V. J. Hruby, W. M. Kazmierski, R. J. Knapp, A new type of synthetic peptide library for identifying ligand-binding activity. Nature 1991, 354, 82-84. 

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Lee JS, Kim YK, Vendrell M et al (2009) Diversity-oriented fluorescence library approach for the discovery of sensors and probes. Mol BioSyst 5 411—421... 

Diversity-Oriented Fluorescence Library Approach for Novel Sensor Development... 

Fig. 17.3 Target-oriented approach and diversity-oriented fluorescence library approach...

Based on this unprecedented high selectivity of G49 to GTP and its visual green fluorescence increase, we dubbed this compound GTP Green. This is a clear example that unexpected molecular interactions could happen and be discovered through a diversity-oriented fluorescence library approach, even within two small molecules. 

M. Vendrell, J. S. Lee, Y. T. Chang, Diversity-oriented fluorescence library approaches for probe discovery and development. Curr. Opin. Chem. Biol 2010, 14, 383-389. 

S. L. Wang, Y. T. Chang, Discovery of heparin chemosensors through diversity oriented fluorescence library approach. Chem. Common. 2008, 1173-1175. 

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