Disordered proteins overview

Thanks to the pioneering works of many research groups, solid-state NMR is now a well established spectroscopy for the study of biological solids, particularly for those with inherent structural disorder such as amyloid fibrils. We have provided an overview of a rather complete set of NMR techniques which have developed for samples prepared by chemical synthesis or protein expression. There are many different ways to present the materials discussed in this review. We hope that the way we have chosen can give a snapshot of some facets of the very exciting discipline of biological solid-state NMR spectroscopy. In spite of the success of solid-state NMR as a tool in biological study, it is not yet a mature technique and there is much room for further development. Below we will speculate on a few possibilities from our own perspective. 

In this chapter, we will review the evidence suggesting a role for specific synaptic vesicle-associated proteins in schizophrenia. First, we present a brief overview of the synaptic vesicle cycle in the broader context of synaptic neurotransmission at chemical synapses. We then describe the experimental evidence linking specific molecular components of the synaptic vesicle to schizophrenia. Since not all synaptic vesicle proteins have been studied in relationship to schizophrenia, this review focuses only on those proteins for which such an effort was made. Finally, we describe the potential roles these proteins could play in the context of current etiological theories of schizophrenia, and discuss the relevance of the experimental findings in the context of this enigmatic disorder. 

Deng, X., Eickholt, J., Cheng, J. (2012) A comprehensive overview of computationeil protein disorder prediction methods. Mol Biosyst, 8(1), 114-121. 

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