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Disintegrates compression force

FIG. 12. The averaged effect of disintegrant, compression force, and lubricant on the release of hydrochlorothiazide from anhydrous lactose-based capsules. Control = 0% disintegrant. (Replotted from Ref. 47.)... [Pg.288]

Fig. 22 Averaged effect of disintegrant, lubricant, and compression force on hydrochlorothiazide dissolution from dicalcium phosphate-based capsules. (From. Ref. 133.)... Fig. 22 Averaged effect of disintegrant, lubricant, and compression force on hydrochlorothiazide dissolution from dicalcium phosphate-based capsules. (From. Ref. 133.)...
The effect that compression force can have on the disintegration efficiency seems, therefore, largely dependent on the mechanism of the disintegrant action. The effectiveness of swelling or structure recovery may well be dependent on attaining a compression force that achieves a critical porosity in the matrix. On the other hand, the capillary uptake of liquid, which is a necessary precursor to these mechanisms could be compromised if the tablet matrix is compressed to a porosity too low. [Pg.284]

Run Binder (%) Lubricant (%) Disinte-grant (%) Glidant (%) Water (%) Compression force (kN) Disintegration Hardness (Kp) time (secs) Friability (%) ... [Pg.395]

During scale-up of a bilayered tablet, it is necessary to determine the range of tamping that can be tolerated for a product. Typically, the tamping force and overall compression force are varied and the tendency to laminate is observed. In addition, the other tablet characteristics are also determined, e.g., hardness, thickness, weight uniformity, disintegration, and dissolution. [Pg.405]

Compression force Thickness Disintegration time Dissolution Dosage form uniformity... [Pg.54]

Lot No. Lube Blend Time (min) Compression Force (kN) Average Hardness (kP) Disintegration Time Dissolution (%) (Mean of Six Tablets) (Range of Values) ... [Pg.150]

Mean tablet hardness and hardness variability may influence the resulting dissolution profile, disintegration times, and tablet appearance. As shown in Table 6.16, the compression force strongly influences mean tablet hardness, while the dissolution profile and disintegration times are largely unaffected. [Pg.154]

Compression force Friability Dissolution profile Disintegration time... [Pg.189]

Riippi, M., Antikainen, O., Niskanen,T., and Yliruusi, J. (1998),The effect of compression force on surface structure, crushing strength, friability, and disintegration time of erythromycin acistrate tablets, Eur. J. Pharm. Biopharm., 46, 339-345. [Pg.1125]

FIGURE 2.41 Hardness and disintegration time as a function of compression force for different particle size of chitin-Mg silicate coprecipitate. Tablets were 12 mm in diameter and 400 mg in weight. [Pg.90]

See other pages where Disintegrates compression force is mentioned: [Pg.303]    [Pg.367]    [Pg.368]    [Pg.277]    [Pg.283]    [Pg.284]    [Pg.284]    [Pg.286]    [Pg.397]    [Pg.399]    [Pg.420]    [Pg.428]    [Pg.150]    [Pg.180]    [Pg.196]    [Pg.445]    [Pg.921]    [Pg.921]    [Pg.191]    [Pg.85]    [Pg.89]    [Pg.915]    [Pg.1109]    [Pg.1111]    [Pg.1459]    [Pg.3557]    [Pg.3561]    [Pg.3561]    [Pg.3562]    [Pg.3562]    [Pg.3565]   
See also in sourсe #XX -- [ Pg.3561 ]



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