Anhydrous lactose

Lactose (hydrated). Lactose (anhydrous) 2031 223 + 52-5 200 — Octa-acetate, a- 152, P- 90 mucic acid, 213... 

ORAP Pimozide 1, 2 mg Tablet Tourette s disorder Blockade dopaminergic receptors in the CNS Calcium stearate, MCC, lactose anhydrous, corn starch Gate... 

LOTRONEX Alosetron HC1 0.5, 1 mg Tablet For women with severe diarrhea-predominant irritable bowl syndrome A potent and selective 5-HT3 antagonist Lactose anhydrous, magnesium stearate, MCC, pregelatinized starch GSK... 

Pharmatose DCL 22 Lactose anhydrous NF DT Lactose anhydrous NF DT High Velocity DMV International Kerry Bio-Sciences Kerry Bio-Sciences 0.67 g/mL 15% <45 pm, 35% <150 pm, 75% <250 pm 35-50% >180 pm 40-60% >180 pm, 15-35% >250 pm Good for low and high drug dose Good compactibility, low friability, good dissolution, improved moisture stability Faster flow and improved tablet uniformity... 

Kerry Bio-Sciences (Sheffield Products). 2006. Technical Literature Lactose monohydrate NF 180 MS HV, lactose anhydrous NF DT, lactose anhydrous NF DT high velocity. 

Anhydrous lactose-anhydrous lactitol Pharmatose DCL40 DMV... 

Lactose occurs as white to off-white crystalline particles or powder. Several different brands of anhydrous lactose are commercially available which contain anhydrous P-lactose and anhydrous a-lactose. Anhydrous lactose typically contains 70-80% anhydrous P-lactose and 20-30% anhydrous a-lactose. 

Lactose anhydrous should be stored in a well-closed container in a cool, dry place. 

Lactose anhydrous is incompatible with strong oxidizers. When mixtures containing a hydrophobic leukotriene antagonist and anhydrous lactose or lactose monohydrate were stored for six weeks at 40°C and 75% RH, the mixture containing anhydrous lactose showed greater moisture uptake and drug degrada-... 

Studies have also shown that in blends of roxifiban acetate (DMP-754) and lactose anhydrous, the presence of lactose anhydrous accelerated the hydrolysis of the ester and amidine... 

Lactose anhydrous has been used experimentally in hydrophilic matrix tablet formulations and evaluated for dry powder inhalation applications. Partial hydration of anhydrous lactose increases the specific surface area and reduces the flow properties of powders but has no effect on compactibility. A specification for lactose is included in the Food Chemicals Codex (FCC) see Factose, Monohydrate. The EINECS number for lactose anhydrous is 200-559-2. 

Other directly compressible lactoses are spray-dried lactose and anhydrous lactose. See Lactose, Spray-Dried, Lactose, Anhydrous. 

In the solid state, lactose appears as various isomeric forms, depending on the crystallization and drying conditions, i.e. a-lactose monohydrate, P-lactose anhydrous, and a-lactose anhydrous. The stable crystalline forms of lactose are a-lactose monohydrate, P-lactose anhydrous, and stable a-lactose anhydrous. 

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