Disinfectants cetylpyridinium chloride

The chemical modification of CS biopolymers via reductive amination, to yield alkylated CS derivatives, and further quaternisation result in very efficient antibacterial materials the degree of activity is correlated to the length of the alkyl chain and bacterial strain. The most active CS derivatives are more selective at killing bacteria than the quaternary ammonium disinfectants, cetylpyridinium chloride and benzalkonium chloride, and AMP. Vanillin can be used as a crosslinker of CS nsing this approach, functionalised antimicrobial polymers based on CS, vanillin. Tween 60 and so on may be easily prepared. Imino-CS biopolymer films, prepared by the acid condensation of the amino groups of CS with various aldehydes, can be used as functional biodynamic materials. 

Microbial degradation of biocides has been described by Hugo [72] who points out that soil organisms are able to break down substances such as phenols added as fumigants. He also reviewed the utilization by bacteria of aromatic compounds (including the preservatives cresol, phenol, benzoic acid and esters of 4-hydroxybenzoic acid). Several types of preservatives and disinfectants, such as the QACs (e.g. cetrimide, cetylpyridinium chloride, benzalkonium chloride), chlorhexidine and phenylethanol can also be inactivated. Significantly, this only occurs at concentrations well below inhibitory or in-use concentrations [33] and thus cannot be responsible for insusceptibility. A further comment about chlorhexidine is given below. 

Quaternary ammonium compounds are surface-active agents. Some of them precipitate or denature proteins and destroy microorganisms. The most important disinfectants in this group are cationic surface-active agents, such as benzalkonium chloride, benzethonium chloride and methylbenzethonium chloride, and cetylpyridinium chloride the problems that they cause are similar. 

Cetylpyridinium chloride is used as a microbicide in disinfectants, in preservatives for cosmetics, as an active ingredient in deodorants. 

An ion containing a nitrogen atom bonded to any combination of four alkyl or aryl groups is classified as a quaternary (4°) ammonium ion. Compounds contain- Quaternary (4°) ammonium ion ing such ions have properties characteristic of salts. Cetylpyridinium chloride is used An ion in which nitrogen is bonded as a topical antiseptic and disinfectant. 

Cetylpyridinium chloride acts highly bactericidal 12mg/l kill Staphylococci, but 170mg/l are required to kill Pseudomonads. The microbicide is mainly used as an active ingredient in antiseptica, e.g. in deodorants, and disinfectants. 

C 2-Cig alkyltrimethyl-, tetrapropyl-, tetrabutyl-, dioctyldimethyl-, and didecyldimethylammonium salts and cetylpyridinium chloride determination in water, disinfectant, and mouthwash Alltech Surfactant/R polydivinyl-benzene, 4.6 X 150 mm Nonlinear gradient from 30 70 to 80 20 CH3CN/O.OO2 M nonafluoro-pentanoic acid Conductivity after chemical suppression 299 0... 

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