Disease mediate interactions

Initial studies examining the function of siderophores in the rhizosphere have focused on practical problems related to agricultural biotechnology. Early research suggested the involvement of siderophores in plant disease suppression by certain root-colonizing pseudomonads (2). Since then, it has become apparent that siderophore-mediated interactions are only part of the story of how microor-... 

Thiocarbamate derivatives, (VI), effective as a4 integrin inhibitors having enhanced resistant to metabolism were prepared by Jackson (6) and used in treating diseases mediated by the binding interaction of a4 integrin such as inflammatory disorders. 

Shin RW, Ogino K, Shimabuku A et al. (2007) Amyloid precursor protein cytoplasmic domain with phospho-Thr668 accumulates in Alzheimer s disease and its transgenic models a role to mediate interaction olAboXAanAxzxi.ActaNeuropatholW i, 627-636. 

The neuropeptide Y (NPY) belongs to a family of peptides that includes peptide YY and pancreatic polypeptide, and it is associated with several diseases such as asthma, immune system disorders, inflammatory diseases, anxiety, depression and diabetes mellitus. NPY is found in the central and peripheral nervous system, and its biological functions are mediated by interactions with five receptor sub-types, i.e. Yl, Y2, Y4, Y5 and Y6. Several studies indicate that the feeding behavior is influenced by interactions between NPY and Yl and Y5. Deswal and Roy used Cerius descriptors and genetic function approximation QSAR to investigate the structural determinants for the inhibition potency of 24 compounds with the general structure 4 for the NPY Y5 receptor [31]. The best QSAR (H = 0.720,... 

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