Disease-associated genes

G. Alternative Splicing Within Disease-Associated Genes. 429... 

Our own data may summarized as follows. To benchmark the mining our method and also to provide access to information of medical interest, study focused on a subset of 500 human genes, called disease-associated genes, because experimental data on genetic variation and trait associa-... 

Fig. 10.11 Schematic diagram of a drug screening concept. Disease-associated genes are identified using different display technologies. Probes for disease-associated genes are designed and are spotted onto the porous chip. Libraries of pharmaceutical compounds are screened against a validated cell model...

Reiter LT, Potocki L, Chien S et al (2001) A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res 11 1114-1125... 

Tan Q, Yashin AI, Bladbjerg EM, de Maat MP, Andersen-Ranberg K, Jeune B, Christensen K, Vaupel JW. Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity. Exp Gerontol 2001 36 1303-1315. 

Genetic variations occur for drug metabolism, drug transporter, and drug target proteins, as well as disease-associated genes. 

In 2005, the first phase was completed with the identification of >50 disease-associated genes. On October 17, 2007, the second phase linked type 2 diabetes, Crohn s disease, elevated blood cholesterol, rheumatoid arthritis, multiple sclerosis, and prostate cancer to mutated genes. The project has catalogued >2.8 million SNPs in individual human genes. 

Automatic text datamining is an important source of knowledge, with many applications in generating databases from scientific literature, such as protein-disease associations, gene expression patterns, subcellular localization, and protein-protein interactions. 

Jacob LS et al (2011) Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sd Signal 4aa4... 

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