Discordant indicator

Using the global concordance and discordance indices, the relative performance of each pair of domain solutions is finally evaluated by calculating each element of the outranking matrix o i, y] using the following equation ... 

The poly(ADP-ribose) polymerase gene (column 2) was detected as 2.3,7.0, 8.0, and 25 kb hybridizing bands (27 positive hybrids) in EcoKl digests of human-rodent somatic cell hybrid DNAs or as a 5.3 kb sequence (column 3) or 6.8 kb band (column 4). Detection of each sequence, or group of sequences, is correlated with the presence or absence of each human chromosome in the somatic cell hybrids. Discordancy indicates the presence of hybridizing sequences in the absence of the chromosome or absence of the hybridizing bands despite the presence of the chromosome the sum of these numbers divided by total hybrids examined (XI00) represents percent discordancy. The human-hamster hybrids consisted of 26 primary clones and 15 subclones and the human-mouse hybrids contained 13 primary hybrids and 42 subclones. The 5.3 kb and 6.8 kb human poly(ADP-ribose) polymerase sequences were detected in 35 and 54 hybrid cell DNAs, respectively. 

The literature on RM certification indicates that there are two broad types of approaches for the characterization of RMs (i) statistical, and (2) measurement. The statistical approach relies on the in-depth application of statistical calculations to a body of analytical results obtained from diverse exercises, often widely scattered and discordant. The approach based on measurement emphasizes laboratory measurement aspects and deals more in detail with various diverse analytical measure-... 

Figure 5.7 Comparison of four-parameter fy-maxi mum, v-minimum. IC50, and h) and two-parameter (IC50 and h) fits of non-ideal concentration-response data. In panels A and B the data indicate a nonzero plateau at low inhibitor concentration that might reflect a low-amplitude, high-affinity second binding interaction. In panels C and D the data indicate a plateau at high inhibitor concentration that does not achieve full inhibition of the enzyme. There could be multiple causes of behavior such as that seen in panels C and D. One common cause is low compound solubility at the higher concentrations used to construct the concentration-response plot. Note that the discordance between the experimental data and the expected behavior is most immediately apparent in the plots that are fitted by the two-parameter equation.

Fig. 1. Left side microphotographs of visible gold occurrences in relation to pyrite crystals. Right side related micro-XRF elemental mapping of As and spot location of LA-ICP-MS analyses with As values (ppm). The exact location of the micro-XRF map is indicated by the white square on the microphotographs (left side). On right side images, the light grey pixels indicate a relative enrichment of As in pyrites. For reference, the white contorted lines are the pyrite crystal borders. White and black spots are As-rich and As-poor portions of pyrites respectively. Note the discordant aspect of the As-enrichment corridors relative to the pyrite crystals and the sharp transition from As-poor and As-rich zones indicated by the LA-ICP-MS analytical As values.

The chemistry of the amido- and imido-diphosphoric acids is not in a satisfactory state. The interpretation of the experimental work by different investigators is discordant, showing a lack of precise facts. The reports of the preparation and properties of the three amidophosphoric acids indicated above are largely based upon the work of J. H. Gladstone and J. D. Holmes.1 A. Mente s and H. N. Stokes re-survey of the field outlined by J. H. Gladstone and J. D. Holmes shows that the interpretation of the results was probably erroneous in other words, the amido-diphosphoric acids reported by J. H. Gladstone and J. D. Holmes may really be imido-diphosphoric acids, or mixtures of the same with meta- and pyro-phosphoric acids. A number of amidopyrophosphoric acids have been... 

At this point, it may be interesting to indicate that the fact that the G-C pairs constitute the unstable part of the genome and that they mutate spontaneously more frequently than the A-T pairs has been reported in a number of publications.180-182 One cannot and should not, however, conclude from this situation that miscouplings through tautomerization of bases are the principal cause of spontaneous mutations, because those are definitely known to be due to a large series of causes, the relative importance of which is difficult to ascertain. The concordance between the theoretical predictions and the experimental facts is, however, worthwhile stressing, as an eventual discordance would certainly have been by some. 

There are some discordant experimental decomposition studies [87], but the thermodynamic data (Tables 4.127 to 4.129) indicate stability to near 1500 K. Data for SrO are in Table 2.79. 

Several studies using brief hypothermia have not found evidence of CA1 protection (18-22). However, such discordant findings are easily explained by a mismatch between the duration of hypothermia and the severity of the ischemic insult. For example, Chopp et al. (12) found that 2 h of postischemic hypothermia reduced CA1 loss against 8 but not 12 minofischemiainrats. Similarly, other experiments indicate thatthe duration of hypothermia is critical (14,17), as very brief cooling (e.g., 0.5 h) was ineffective while somewhat longer durations were (e.g., 5 h) protective, perhaps only transiently. 

Dynamic NMR studies of W(CO)(HC=CH)(S2CNEt2)2 and related complexes (58) indicate that the barrier to alkyne rotation is around 11-12 kcal/mol (Table IV). Discordant metal-ligand 77 interactions anticipated as the alkyne rotates away from the ground state orientation are evident in EHMO calculations (Fig. 23). When the alkyne is orthogonal to the M—CO axis the dyz orbital is stabilized by CO it but destabilized by alkyne ir while dxy becomes the lowest lying dir orbital due to... 

Example 1.2 TU and 48.3 pmc were found in well 1572, Hanahai, Botswana. What is the age of this water The values represent a forbidden combination 1.2 TU indicates pre-bomb (an age of a few decades), whereas 48.3 pmc indicates water a few thousand years old. In other words, the tritium and 14C ages are discordant (disagreeing), and neither is correct. The combination could be formed only by intermixing of old water (zero tritium and < 48.3 pmc) with recent water (post-bomb tritium and post-bomb 14C). This example is of great importance. Concordant ages (agreeing ages)... 

Answer 11.4 This is a forbidden combination of high tritium and low 14C, leading to discordant ages 6TU indicates a post-1952 age and 6pmc indicates an age of several tens of thousands years. This is a mixture of post-1952 water with very old water (OTU, Opmc). 

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