Amidophosphoric acids

The following series of amidophosphoric acids has been reported ... 

By abstracting the elements of ammonia from the di- and tri-amidophosphoric acids, a series of imido-compounds has been prepared these are represented by ... 

The chemistry of the amido- and imido-diphosphoric acids is not in a satisfactory state. The interpretation of the experimental work by different investigators is discordant, showing a lack of precise facts. The reports of the preparation and properties of the three amidophosphoric acids indicated above are largely based upon the work of J. H. Gladstone and J. D. Holmes.1 A. Mente s and H. N. Stokes re-survey of the field outlined by J. H. Gladstone and J. D. Holmes shows that the interpretation of the results was probably erroneous in other words, the amido-diphosphoric acids reported by J. H. Gladstone and J. D. Holmes may really be imido-diphosphoric acids, or mixtures of the same with meta- and pyro-phosphoric acids. A number of amidopyrophosphoric acids have been... 

Disodium monoamidophosphate is formed when mono-amidophosphoric acid diphenyl ester reacts with stoichiometric amounts of sodium hydroxide.1... 

Monoamidophosphoric acid is prepared by the Stokes method. Phenol and POCI3 are reacted to form the diphenyl ester of mono-chlorophosphoric acid. The latter is reacted with alcoholic ammonia to give the phenyl ester of monoamidophosphoric acid. Monoamidophosphoric acid is formed on saponification of the ester with KOH. It is isolated as the potassium salt, from which,according to Klement and Becht, free amidophosphoric acid can be obtained by reaction with HCIO 4 ... 

According to Klement, free amidophosphoric acid can also be obtained by reaction of a solution of the acid potassium salt with a cation exchanger that is not too strongly acidic. 

Arnrmmoaquophos-phoric Adds H2NP0(0H)2 Amidophosphoric acid... 

Amnionoaquo- and Ammonophosphorous Adds H2NP(0H)2 Amidophosphorous acid... 

Thiotn amidophosphoric acids (35) are isoelectronic with phosphoric acids and were initially reported from the reaction of phosphorus pentasulfide with primary amines at high temperatures. Subsequently, an improved synthesis for 35 with increased yields and milder conditions has been reported involving the room temperature reaction of thiophosphoryl chloride and primary amines (Equation 50). The most convenient route to the analogous selenium derivatives SeP(NHPh)3 is from the oxidation of P(NElPh)3 with elemental selenium (Equation 51). Also isoelectronic with phosphoric acids are dithioiwamido-phosphoric acids (36), which can be prepared from the reaction of phosphorus pentasulfide with an excess of primary amine at 30°C in toluene (Equation 52). The selenium derivatives of 36 can be prepared in a similar reaction from phosphorus (V) selenide, although due to their increased acidity... 

Some new amidophosphoric acid esters containing substituted pyridine moieties have been synthesized and characterized by H, P H) NMR, IR, and mass spectrometry. The study, synthesis, and spectroscopic characterization of phosphonates has been well documented during 2008 and several papers are worthy of mention. Starting with a-aminophosphonates and on a green chemistry theme, three types of D,D-diethyl V-dehy-droabietic a-aminoaryhnethylphosphonates have been synthesized from natural product derivatives following a two-step, solvent-free reaction... 

In the early 60 s, working with N.P. Dubinin, I investigated the cytogenetic effect of alkylating agent phosphemidiun (lat. synonym phosphemid, phosphasin)—di-(ethylene imid)-pyrimidyl-2-amidophosphoric acid (Fig. 1). 

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