Direct molecular imaging

Altelaar, A. F., van Minnen, J, Jimenez, C. R., Heeren, R. M., and Piersma, S. R. (2005). Direct molecular imaging of Lymnaea stagnalis nervous tissue at subcellular spatial resolution by mass spectrometry. Anal. Chem. 77 735-741. 

Carlisle Cl, King DA. Direct molecular imaging of NO monomers and dimers and a surface reaction on Ag(lll). J Phys Chem B. 2001 105 3886-93. 

Khatib-Shahidi, S., Andersson, M., Herman, J. L., Gillespie, T. A., and Caprioli, R. M. (2006). Direct molecular analysis of whole-body animal tissue sections by imaging MALDI mass spectrometry. Anal. Chem. 78 6448-6456. 

Most of the drugs currently in study aim at the treatment of chronic disorders and need to be administered for a prolonged period of time. The efficacy of the treatment is evaluated mainly by the study of the model disease and evaluating recovery from the pathological status. The availability of appropriate models where the direct effect of a treatment on the drug target can be measured directly tremendously improves the predictability of preclinical studies. Furthermore, the whole body molecular imaging followed by the study of the molecular events elicited by the treatment of the experimental animal may reveal unexpected effects in tissues for example, where the repeated administration of the compound may cause toxicity (e.g., liver or others). For the... 

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