Dipropylacetic acid

Valproic acid is the common name for 2-propylpentanoic acid (Epival usually used as its sodium salt), also referred to as n-dipropylacetic acid, is a simple branched-chain carboxylic acid with unique anticonvulsant properties. Valproic acid was first synthesized in 1882 by Burton [75], but there was no known clinical use until its anticonvulsant activity was fortuitously discovered by Pierre Eymard in 1962 in the laboratory of G. Carraz, which was published by Meunier et al. in 1963 [76]. [Pg.231]

Sodium valproate is sodium 2-propylpentanoate. It is also known as sodium dipropylacetic acid, sodium 2-propylvalerate, sodium dipro-pylacetate, sodium di-n-propylacetate, and by many slight variations of the particular nomenclature. [Pg.530]

Valproic acid (dipropylacetic acid) is a single branched chain carboxylic acid that is structurally unlike any of the other drugs used in the treatment of bipolar disorder or epilepsy. The amide derivative, valproamide, is available in Europe as a more potent form of valproate. Valproate was first developed in Erance as an antiepileptic agent in 1963. As an antiepileptic agent, it was shown to be active against a variety of epilepsies without causing marked sedation. [Pg.205]

Valproic acid, valproate sodium, and (DVP) are carboxylic acid-derivative anticonvulsants. Divalproex sodium is a stable coordination compound consisting of valproic acid and valproate sodium in a 1 1 molar ratio (AHFS, 2000). It is a pro-drug of valproate, dissociating into valproate in the GI tract (AHFS, 2000), and a simple branched-chain carboxylic acid (w-dipropylacetic acid) with antiepileptic activity against a variety of types of seizures (Beydoun et al., 1997). Divalproex sodium has been approved for treating adults with simple and complex absence seizures (Mattson et al., 1992), and for mania. It has shown efficacy across a broad spectrum of BD subtypes (i.e., pure mania, mixed mania, and rapid cycling) (Pope et al., 1991 Bowden et al., 1994). [Pg.317]

Valproic acid is a carboxylic acid designated as 2-propyl-pentanoic acid. It is also known as dipropylacetic acid. Capsules and syrup are antiepileptics for oral administration. Each soft elastic capsule contains 250 mg valproic acid. [Pg.205]

Dipropyl acetic acid or valproic acid may be prepared the next way. Propylbromide is mixed with cyanacetic acid in the presence of sodium ethylate, made from absolute ethanol and sodium. By that prepared a,a-dipropylcyanacetic acid ethyl ester is saponified with equimolecular amounts of NaOH to give dipropylacetonitril. The desired dipropylacetic acid is produced by saponification of dipropylacetonitryl with aquatic NaOH. It is colorless liquid. BP 219°-220°C. [Pg.1370]

Dipropylacetic acid (40) protected rats against picrotoxin and pentetrazole.88 The chelating agent D-penicillamine (41) markedly reduced seizures in P. Papio baboons, a primate with high serum Zn levels.89... [Pg.15]

Sou, Chem. Abstracts, 1936, 30, 4463. Dipropylacetic Acid (HeptaneA.earboxylic acid, l-propylvaleric acid)... [Pg.1058]

Rapid Determination of the Antiepileptic Drug Dipropylacetic Acid in Serum... [Pg.63]

Contribution to the Study of the Metabolism of Dipropylacetic Acid and Dipropylacetamide. I. Identification and Assay in Urine by Gas Chromatography Ann. Pharm. Fr. 33(6-7) 355-363 (1975) CA 84 99052n... [Pg.200]

Propionic Acid and Dipropylacetic Acid in the Urine of Patients Treated with Dipropylacetic Acid Clin. Chim. Acta 74(1) 39-42 (1977) CA 86 100689a... [Pg.224]

Six amides derived from dipropylacetic acid (e.g. XXVI) were reported to have tranquilizing properties in mice 2uid are scheduled for extensive pharmacological evaluation. [Pg.8]

Schmid, R.D. (1977), Propionic acid and dipropylacetic acid in the urine of patients treated with dipropylacetic acid. Clin. Chim. Acta, 74,39. [Pg.207]

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