1,3-Diphosphoglyceric acid cells

In certain contemporary organisms, for instance, bacteria and fungi, 3-phospho-D-glyceroyl-phosphate polyphosphate phosphotransferase activity was found (Kulaev and Bobyk, 1971 Kulaev et al., 1971). The phosphate was transferred from 1,3-diphosphoglyceric acid, not to ADP to form ATP, as one could expect from the Meyerhof-Embden-Parnas scheme, but directly to PolyP. This fossil reaction was most expressed in an adenine deficient yeast mutant under cell adaptation to ATP depletion. 

This reaction can only continue till all the substrate is used up, if the reaction product, which is 1,3-diphosphoglyceric acid, is removed from the solution in the cell, this add then reacts with ADP, converting it into ATP the enei -rich anhydride bond then disappears... 

Dische, Z., 1941, Interdependence of various enzymes of the glycolytic system and the automatic regulation of their activity within the cells. I. Inhibition of the phosphorylation of glucose in red corpuscles by monophosphoglyceric and diphosphoglyceric acids state of the diphosphoglyceric acid and the phosphorylation of glucose, Trav. Membres Soc. Chim. Biol. 23 1140. 

Ascorbic acid appears to be toxic to certain tumor tissues however, it may increase the biological effectiveness of red blood cells by increasing the level of 2,3-diphosphoglycerate (30,31), 2,3-Diphosphoglycerate is essential to maintaining the normal oxygen dissociation curve of hemoglobin. This increase has been shown in vitro (30) and in vivo, in human subjects (31). 

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